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We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1(More)
The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, which is needed for touch sensitivity in Caenorhabditis(More)
Our research suggests that knowledge is shared and created in online communities of practice through the establishment of processes and 'technologies' that enable virtual re-experience for the learners at various levels. Three questions guided our research. The first one concentrates on how community members organize content with regard to their daily(More)
In this paper we introduce a computational method for proving the existence of generic saddle-to-saddle connections between equilibria of first order vector fields. The first step consists of rigorously computing high order parametrizations of the local stable and unstable manifolds. If the local manifolds intersect, the Newton-Kantorovich theorem is(More)
The Tso Kar lake basin in Ladakh, northwestern Himalayas (33 18 0 N, 78 E, 4527 m a.s.l.) is located close to the modern boundary of effective moisture transport from the Indian summer monsoon. In order to reconstruct the possible monsoonal impact on the hydrology of the lake basin during the last 15 kyr, we studied the geomorphology of the basin and(More)
A computational method based on Chebyshev series to rigorously compute solutions of initial and boundary value problems of analytic nonlinear vector fields is proposed. The idea is to recast solutions as fixed points of an operator defined on a Banach space of rapidly decaying Chebyshev coefficients and to use the so-called radii polynomials to show the(More)
Disablingmutations in genomemaintenance andDNA repair pathways are frequently observed in cancer. These DNA repair defects represent genetic aberrations that are specific to cancer cells and not present in healthy tissues. It is thought that these molecular defects produce a "mutator phenotype," which allows incipient cancer cells to accumulate additional(More)
1. G.J. Tserevelakis, G. Filippidis, E.V. Megalou, C. Fotakis, N. Tavernarakis “Cell tracking in live Caenorhabditis elegans embryos via Third Harmonic Generation imaging microscopy measurements” Journal of Biomedical Optics 16, 046019 (2011) 2. R. Aviles-Espinosa, G. Filippidis, C. Hamilton, G. Malcolm, K.J. Weingarten, T. Südmeyer, Y. Barbarin, U. Keller,(More)
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