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  • Ursula Ehmer, Arndt Vogel, Jan Karl Schütte, Britta Krone, Michael P Manns, Christian P. Strassburg
  • Medicine, Biology
  • Hepatology
  • 2004 (First Publication: 25 March 2004)
  • UDP-glucuronosyltransferases are a family of drug metabolizing enzymes contributing to hepatic drug metabolism and protection against environmental toxins. The aim of this study was to identifyExpand
  • Christian P. Strassburg, K Oldhafer, Michael P Manns, Robert H. Tukey
  • Medicine, Biology
  • Molecular pharmacology
  • 1997 (First Publication: 1 August 1997)
  • Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine individual proteins. The different proteins are generated by exon-sharing,Expand
  • Tim Oliver Lankisch, Arndt Vogel, +5 authors Christian P. Strassburg
  • Biology, Medicine
  • Molecular Pharmacology
  • 2005 (First Publication: 1 May 2005)
  • UDP glucuronosyltransferases (UGT) detoxify bilirubin and therapeutic drugs, a process influenced by single nucleotide polymorphisms (SNPs) in their structural genes and promoter elements. UGT1A1*28Expand
  • Barbara Grams, Andrea Harms, Stephan J. Braun, Christian P. Strassburg, Michael P Manns, Petra Obermayer-Straub
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 2000 (First Publication: 1 May 2000)
  • UDP-Glucuronosyltransferases (UGT) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic substrates. The resulting glucuronides are more hydrophilic, facilitating renal andExpand