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A number of algorithms for brain segmentation in preterm born infants have been published, but a reliable comparison of their performance is lacking. The NeoBrainS12 study (http://neobrains12.isi.uu.nl), providing three different image sets of preterm born infants, was set up to provide such a comparison. These sets are (i) axial scans acquired at 40 weeks(More)
PURPOSE Volumetric measurements of neonatal brain tissues may be used as a biomarker for later neurodevelopmental outcome. We propose an automatic method for probabilistic brain segmentation in neonatal MRIs. MATERIALS AND METHODS In an IRB-approved study axial T1- and T2-weighted MR images were acquired at term-equivalent age for a preterm cohort of 108(More)
BACKGROUND Emphysema and small airway disease both contribute to chronic obstructive pulmonary disease (COPD), a disease characterised by accelerated decline in lung function. The association between the extent of emphysema in male current and former smokers and lung function decline was investigated. METHODS Current and former heavy smokers participating(More)
This paper discusses a module-based vision for designing BDI-based multi-agent programming languages. The introduced concept of module is generic and facilitates the implementation of different agent concepts such as roles and agent profiles, or to adopt common programming techniques such as encapsulation and information hiding. This vision is applied to(More)
Despite much research on companion robots and affective virtual characters, a comprehensive discussion on a generic architecture is lacking. We compile a list of possible requirements of a companion robot and propose a generic architecture based on this list. We explain this architecture to uncover issues that merit discussion. The architecture can be used(More)
OBJECTIVES To determine the influence of iterative reconstruction (IR) on quantitative computed tomography (CT) measurements of emphysema, air trapping, and airway wall and lumen dimensions, compared to filtered back-projection (FBP). METHODS Inspiratory and expiratory chest CTs of 75 patients (37 male, 38 female; mean age 64.0 ± 5.7 years) were(More)
OBJECTIVES To determine the variation in quantitative computed tomography (CT) measures of air trapping in low-dose chest CTs of heavy smokers. METHODS We analysed 45 subjects from a lung cancer screening trial, examined by CT twice within 3 months. Inspiratory and expiratory low-dose CT was obtained using breath hold instructions. CT air trapping was(More)
OBJECTIVE To determine the agreement and reliability of fully automated coronary artery calcium (CAC) scoring in a lung cancer screening population. MATERIALS AND METHODS 1793 low-dose chest CT scans were analyzed (non-contrast-enhanced, non-gated). To establish the reference standard for CAC, first automated calcium scoring was performed using a(More)
OBJECTIVES To evaluate the reliability of semiquantitative Vertebral Fracture Assessment (VFA) on chest Computed Tomography (CT). METHODS Four observers performed VFA twice upon sagittal reconstructions of 50 routine clinical chest CTs. Intra- and interobserver agreement (absolute agreement or 95% Limits of Agreement) and reliability (Cohen's kappa or(More)