Christian Magnus Page

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BACKGROUND Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and infection with parasites have been proposed to influence MS risk. The aim of this study was to investigate the influence of various(More)
OBJECTIVE Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. METHODS Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethylation450K BeadChip. Genotype data were used to assess(More)
Ce rapport présente une brève description de la méthodologie utilisée pour la désa-grégation d'échelle des simulations climatiques, les données utilisées comme base pour la désagrégation, ainsi qu'une description des scénarii désagrégés disponibles. Les limites scientifiques d'utilisation de ces données de même que leurs sources d'incertitude sont(More)
Ce rapport présente une brève description de la méthodologie utilisée pour la désa-grégation d'échelle des simulations climatiques, les données utilisées comme base pour la désagrégation, ainsi qu'une description des scénarii désagrégés disponibles. Les limites scientifiques d'utilisation de ces données de même que leurs sources d'incertitude sont(More)
BACKGROUND Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS(More)
Many studies have highlighted significant interactions between soil C reservoir dynamics and global climate and environmental change. However, in order to estimate the future soil organic carbon sequestration potential and related ecosystem services well, more spatially detailed predictions are needed. The present study made detailed predictions of future(More)
Genotyping chips for rare and low-frequent variants have recently gained popularity with the introduction of exome chips, but the utility of these chips remains unclear. These chips were designed using exome sequencing data from mainly American-European individuals, enriched for a narrow set of common diseases. In addition, it is well-known that the(More)
Depression has been linked to an imbalance in cortisol. Until recently, cortisol has been studied by measuring concentrations at single time points in blood or saliva samples. Cortisol concentrations vary with circadian rhythm and experiences, from time point to time point. The measurement of hair cortisol concentration (HCC) is a new method of accessing(More)
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