Christian M. Hodel

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Testicular side effects of procarbazine (Proc: 50 or 200 mg/kg i.p.), vincristine (Vin: 0.15 or 0.6 mg/kg i.p.) or busulfan (Bu: 10 mg/kg p.o.) were examined by morphological methods 3 days, 1 week and weekly thereafter until week 10 after a single exposure. With Proc a degeneration of the germ cells, particularly of mid primary spermatocytes, was seen(More)
Newer histopathologic techniques were used in combination with sperm head counts (SHC) and serial mating (SM) studies to assess different aspects of testicular toxicity. Adult male rats were treated once intraperitoneally (i.p.) with vincristine (Vin: 0.15 and 0.6 mg/kg) or procarbazine (Proc: 50 and 200 mg/kg). Investigations were performed at weekly(More)
Toxicology, as a multidisciplinary field, provides career opportunities for graduates with medical (human or veterinarian), pharmacological, pharmaceutical, biological, microbiological, molecular biological, chemical, biochemical, genetic or other backgrounds. However, in today's environment specialists with a university degree in toxicology or a(More)
In view of the lack of information regarding careers for toxicologists in Europe, the Individual Members of EUROTOX organised a workshop on careers in toxicology during the EUROTOX Congress 2000 in London. Toxicologists are mainly employed in academia, regulatory agencies, contract research organisations (CROs) and the chemical and pharmaceutical(More)
It is proposed to divide antispermatogenic compounds into four main groups on the basis of the morphological changes which they cause: a) Radiomimetic substances (e.g., Busulfan). These have a direct effect on spermatogonia and hence also on later sperm development. b) Substances inhibiting the meiotic and postmeiotic phases of spermatogenesis. These cause(More)
In view of the lack of information regarding careers for toxicologists in Europe, the Individual Members of EUROTOX organised a workshop on careers in toxicology during the EUROTOX Congress 2000 in London. Toxicologists are mainly employed in academia, regulatory agencies, contract research organisations (CROs) and the chemical and pharmaceutical(More)
The International Union of Toxicology (IUTOX) was founded in 1980 in Brussels. The initiative was started by the Society of Toxicology (SOT), USA, and the European Society of Toxicology in 1975 (EST), and the foundation prepared by an Inter Society Liason Committee. Eight National Societies of Toxicology were founding members of IUTOX besides SOT and EST.(More)