RATIONALE Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for the TNF/interleukin-1/Toll-like receptor superfamily. Ligands of this family comprise multiple important cytokines such as TNFα, CD40L, and interleukin-1β that promote chronic inflammatory diseases such as atherosclerosis. We recently reported… (More)
Various models for the nuclear architecture in interphase cell nuclei have been presented, proposing a territorial or a non-territorial organization of chromosomes. To better understand the correlation between nuclear architecture and the formation of chromosomal aberrations, we applied computer simulations to model the extent of radiation induced… (More)
This discussion paper is/has been under review for the journal Atmospheric Chemistry and Physics (ACP). Please refer to the corresponding final paper in ACP if available. Abstract During the 2014 Asia-Pacific Economic Cooperation (APEC) summit, a reduction of air pollution sources was coordinated to ensure good air quality in Beijing and the surrounding… (More)
We present a tool for the simulation and analysis of materials properties. This tool comprises simulation methods for models of materials (metal and polymer materials) as well as sophisticated visualization techniques to explore materials. Here we describe the basic design principles and an example application.