Christian Münkel

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RATIONALE Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for the TNF/interleukin-1/Toll-like receptor superfamily. Ligands of this family comprise multiple important cytokines such as TNFα, CD40L, and interleukin-1β that promote chronic inflammatory diseases such as atherosclerosis. We recently reported(More)
CD40L figures prominently in atherogenesis. Recent data demonstrate elevated levels of sCD40L in the serum of patients with the metabolic syndrome (MS). This study investigated the role of CD40L in pro-inflammatory gene expression and cellular differentiation in adipose tissue to obtain insight into mechanisms linking the MS with atherosclerosis. Human(More)
BACKGROUND Members of the tumor necrosis factor superfamily, such as tumor necrosis factor-alpha, potently promote atherogenesis in mice and humans. Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines. METHODS AND RESULTS This study tested the hypothesis that TRAF1 modulates atherogenesis(More)
Vertical variations of aerosols and the effects responded to the emission control: application of lidar ceilometer in Beijing during APEC, 2014 G. Tang, X. Zhu, B. Hu, J. Xin, L. Wang, C. Münkel, G. Mao, and Y. Wang State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry (LAPC), Institute of Atmospheric Physics, Chinese Academy(More)
This paper describes the application of finite-size scaling concepts to domain growth in systems with a non-conserved order parameter. A finite-size scaling ansatz for the timedependent order parameter distribution function is proposed, and tested with extensive Monte-Carlo simulations of domain growth in the 2-D spin-flip kinetic Ising model. The scaling(More)
Restorative therapy concepts, such as cell based therapies aim to restitute impaired neurotransmission in neurodegenerative diseases. New strategies to enhance grafted cell survival and integration are still needed to improve functional recovery. Anodal direct current stimulation (DCS) promotes neuronal activity and secretion of the trophic factor BDNF in(More)
We present the crumpling transition in three-dimensional Euclidian space of dynamically triangulated random surfaces with edge extrinsic curvature and fixed topology of a sphere as well as simulations of a dynamically triangulated torus. We used longer runs than previous simulations and give new and more accurate estimates of critical exponents. Our data(More)
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