Christian Koehler

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Although the genome of the Mycobacterium tuberculosis H37Rv laboratory strain has been available for over 10 years, it is only recently that genomic information from clinical isolates has been used to generate the hypothesis of virulence differences between different strains. In addition, the relationship between strains displaying differing virulence in an(More)
BACKGROUND Celiac disease is a T-cell mediated chronic inflammatory disorder of the gut that is induced by dietary exposure to gluten proteins. CD4+ T cells of the intestinal lesion recognize gluten peptides in the context of HLA-DQ2.5 or HLA-DQ8 and the gluten derived peptides become better T-cell antigens after deamidation catalyzed by the enzyme(More)
Smart devices are becoming increasingly commercially available. However, uptake of these devices has been slow and abandonment swift, which indicates that smart devices may not currently meet the needs of users. To advance an understanding of the ways users benefit from, are challenged by, and abandon smart devices, we asked a group of users to purchase(More)
The microtubule (MT) cytoskeleton is essential for a variety of cellular processes. MTs are finely regulated by distinct classes of MT-associated proteins (MAPs), which themselves bind to and are regulated by a large number of additional proteins. We have carried out proteome analyses of tubulin-rich and tubulin-depleted MAPs and their interacting partners(More)
Reducing the large energy consumption of temperature regulation systems is a challenge for researchers and practitioners alike. In this paper, we explore and compare two common types of solutions: A manual systems that encourages reduced energy use, and an intelligent automatic control system. We deployed an eco-feedback system with the ability to remotely(More)
Exosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumour-specific molecules can be found in exosomes isolated from biological fluids. We have here investigated the proteome of urinary exosomes by using mass spectrometry to identify proteins differentially expressed in prostate cancer patients compared to healthy male(More)
Location prediction enables us to use a person's mobility history to realize various applications such as efficient temperature control, opportunistic meeting support, and automated receptionists. Indoor location prediction is a challenging problem, particularly due to a high density of possible locations and short transition distances between these(More)
The complexity of image processing tasks has risen during the last years. To counteract this trend, we introduce the novel Domain Specific Language GU-DSL allowing to shorten the time-to-market and improving the development process. Therefor we use some base concepts of Java and C#, adopting the idea of encapsulating classes and flow-models using diagrams(More)
Rising power demands resulting from technological advancements is an increasingly important global issue. One way to tackle this problem is to motivate individual behavior change, for which the ubiquity of mobile phones offer an ideal platform to influence consumption behavior of users. In this paper we explore the possibilities for using timely(More)