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Light sensing is very important for organisms in all biological kingdoms to adapt to changing environmental conditions. It was discovered recently that plant-like phytochrome is involved in light sensing in the filamentous fungus Aspergillus nidulans[1]. Here, we show that phytochrome (FphA) is part of a protein complex containing LreA (WC-1) and LreB(More)
Human glomerulonephritis (GN) is characterized by sustained proteinuria, sodium retention, hypertension, and edema formation. Increasing quantities of filtered protein enter the renal tubule, where they may alter epithelial transport functions. Exaggerated endocytosis and consequent protein overload may affect proximal tubules, but intrinsic malfunction of(More)
Light is one of the most important environmental factors for orientation of almost all organisms on Earth. Whereas light sensing is of crucial importance in plants to optimize light-dependent energy conservation, in nonphotosynthetic organisms, the synchronization of biological clocks to the length of a day is an important function. Filamentous fungi may(More)
Aspergillus nidulans responds to light in several aspects. The balance between sexual and asexual development as well as the amount of secondary metabolites produced is controlled by light. Here, we show that germination is largely delayed by blue (450 nm), red (700 nm), and far-red light (740 nm). The largest effect was observed with far-red light. Whereas(More)
Light is essential for photosynthetic organisms, but also serves as an important environmental cue for non-photosynthetic species; thus, light sensing is evolutionarily conserved throughout the kingdoms, from archaea and fungi to humans. Light sensors are chromoproteins, the low-molecular weight compound of which absorbs specific wavelengths and induces a(More)
STATEMENT OF PROBLEM Metal ceramic restorations are widely used in prosthodontics, but long-term data on their clinical performance in private practice settings based on prospective trials are sparse. PURPOSE This clinical trial was designed to provide realistic long-term survival rates for different outcomes related to tooth loss, crown loss, and metal(More)
Patients with proteinuric kidney diseases often have symptoms of salt and water retention. It has been hypothesized that dysregulated sodium absorption is due to increased proteolytic cleavage of epithelial sodium channels (ENaCs) and increased Na,K-ATPase expression. Microarray analysis identified a reduction in kidney corin mRNA expression in rat models(More)
PURPOSE The aim of this study was to evaluate the clinical performance of metal-ceramic crowns placed in 10 private practices. MATERIALS AND METHODS In this prospective clinical trial, 95 patients were provided with 190 noble-metal metal-ceramic single crowns. RESULTS The 7-year survival rates of the crowns were 95.5% (target event: any removal), 99.5%(More)
OBJECTIVE Changes in biochemical markers of bone formation and resorption were followed over the course of 1 year in premenopausal, perimenopausal and early postmenopausal women. METHODS Sixty-four subjects were analyzed, grouped according to their menstrual pattern, menopausal complaints and endocrinological parameters to be premenopausal (n=20),(More)
Collaborations are a frequently occurring class of crosscutting concerns. Prior work has argued that collaborations are better implemented using Collaboration Languages (CLs) rather than AspectJ-like Languages (ALs). The main argument is that aspects flatten the objectoriented structure of a collaboration, and introduce more complexity rather than benefits(More)