Christian-Jacques Larsen

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Inactivation of both the pRb (pRb-cyclin D1/cyclin-dependent kinase 4/6-p16) and p53 (p53-p21 WAF1-p14 ARF) pathways is thought to be essential for immortalization in vitro and malignant transformation in vivo. We identified different combinations of pRb and p53 pathway alterations in 12 invasive transitional cell carcinomas (TCCs) and addressed the(More)
A central feature of antigen recognition by T lymphocytes is that it occurs only when the antigen is associated on the cell surface with a molecule encoded by the MHC, (2-4). The antigen-MHC recognition unit of the human T cell (T3-Ti) has been defined as a clonotypic, disulfide-linked heterodimer (Ti) composed of one a and one fl chain associated with(More)
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