Christian Henninger

Learn More
We investigated the relevance of signaling mechanisms regulated by the Ras-homologous GTPase Rac1 for survival of acute myeloid leukemia (AML) cells harbouring the MLL-AF9 oncogene due to t(9;11)(p21;q23) translocation. Monocytic MLL-AF9 expressing cells (MM6, THP-1) were hypersensitive to both small-molecule inhibitors targeting Rac1 (EHT 1864, NSC 23766)(More)
The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound signal transducing molecule that is involved in the regulation of cell motility and adhesion as well as cell cycle progression, mitosis, cell death and gene expression. Rac1 also adjusts cellular responses(More)
Literatur [1] Wartlick F, Bopp A, Henninger C et al. (2013) DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. Inhibition of rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis 2:e190 [3] Huelsenbeck SC, Schorr A, Roos WP et al. (2012) Rac1 protein(More)
  • 1