Christian Hafner

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BACKGROUND Activating mutations in the PIK3CA gene have been identified in a variety of human malignancies and are commonly detected in hotspot codons located in the helical and kinase domains in exons 9 and 20. Existing methodologies for the detection of PIK3CA mutations are time-consuming and/or expensive. In the present study we describe the first(More)
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with an increasing incidence. The understanding of the molecular carcinogenesis of MCC is limited. Here, we scrutinized the PI3K/AKT pathway, one of the major pathways activated in human cancer, in MCC. Immunohistochemical analysis of 41 tumor tissues and 9 MCC cell lines revealed high levels of(More)
BACKGROUND Sentinel lymph node spread is a crucial factor in melanoma outcome. We aimed to define the impact of minimal cancer spread and of increasing numbers of disseminated cancer cells on melanoma-specific survival. METHODS AND FINDINGS We analyzed 1,834 sentinel nodes from 1,027 patients with ultrasound node-negative melanoma who underwent sentinel(More)
BACKGROUND Epidermal nevi (EN) represent benign congenital skin lesions following the lines of Blaschko. They result from genetic mosaicism, and activating FGFR3 and PIK3CA mutations have been implicated. CASE PRESENTATION We report a female patient with a systemic keratinocytic nevus also involving the oral mucosa. Molecular genetic analysis revealed a(More)
Keyboard percussion instruments such as xylophones and glockenspiels are composed of an arrangement of bars. These are varied in some of their geometrical properties---typically the length---in order to influence their acoustic behavior. Most instruments in this family do not deviate from simple geometrical shapes, since designing the natural frequency(More)
Highly accurate computations of surface plasmons in metallic nanostructures with various geometries are presented. Calculations for cylinders with irregular cross section, coupled structures, and periodic gratings are shown. These systems exhibit a resonant behavior with complex field distribution and strong field enhancement, and therefore their(More)
In this paper we present a novel method for non-linear shape optimization of 3d objects given by their surface representation. Our method takes advantage of the fact that various shape properties of interest give rise to underdetermined design spaces implying the existence of many good solutions. Our algorithm exploits this by performing iterative(More)
Nanowire-based solar cells opened a new avenue for increasing conversion efficiency and rationalizing material use by growing different III−V materials on silicon substrates. Here, we propose a multiterminal nanowire solar cell design with a theoretical conversion efficiency of 48.3% utilizing an efficient lateral spectrum splitting between three different(More)
Reflective semiconductor optical amplifier fiber cavity lasers (RSOA-FCLs) are appealing, colorless, self-seeded, self-tuning and cost-efficient upstream transmitters. They are of interest for wavelength division multiplexed passive optical networks (WDM-PONs) based links. In this paper, we compare RSOA-FCLs with alternative colorless sources, namely the(More)