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BACKGROUND Evasion of apoptosis is a hallmark of pancreatic cancer. However, the underlying mechanisms are still only partly understood and may involve antiapoptotic proteins such as c-FLIP. Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated. METHODS Expression of c-FLIP(L) and c-FLIP(S)… (More)
The transcription factor nuclear factor-kappaB (NF-kappaB) plays a central role in stress-induced transcriptional activation and has been implicated in chemoresistance of cancers. In the present study, we investigated the role of NF-kappaB in inducible chemoresistance of neuroblastoma. Doxorubicin, VP16 and the cytotoxic ligand TRAIL trigger NF-kappaB… (More)
The present study compared decision-making processing between patients with traumatic brain injury (TBI) and healthy controls. The study also sought to identify dissociations in the frequency of deficits in executive functions (EF) tasks that mainly assess decision making (DM; hot component) and inhibition (cold component) following TBI. The sample was… (More)
This paper explores the potential of acausal modelling tools for a simple, but challenging process engineering benchmark problem. Matlab/Simulink illustrates a traditional block diagram modelling tool, while MathModelica with its strong emphasis on objects and symbolic manipulation was used to demonstrate a novel approach to modelling.
Organic matter content in black liquor inside and outside chips during kraft cooking.netic model structure for softwood kraft cooking.nal pre-processing and cross-validation (IPCV) of PLS models improves error estimates in spectroscopic calibrations.