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Genetic engineering and production of modified fatty acids by the non-conventional oleaginous yeast Trichosporon oleaginosus ATCC 20509
TLDR
This work demonstrates, that T. oleaginosus ATCC 20509 can be used as versatile biotechnology platform to transform industrial waste streams into designed, high value fatty acids.
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The first structure of a bacterial diterpene cyclase: CotB2.
TLDR
The product of mutant CotB2(W288G) produced the new antibiotic compound (1R,3E,7E,11S,12S)-3,7,18-dolabellatriene, which acts specifically against multidrug-resistant Staphylococcus aureus, which opens a sustainable route for the industrial-scale production of this bioactive compound.
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Genetic Engineering of the Oleaginous Yeast Trichosporon oleaginosus and the Bacteria Escherichia coli Aimed at the Production of High Value Lipids and Bioactive Diterpenes
TLDR
Establishment of genetic engineering tools and targeted metabolic engineering of the non-conventional oleaginous yeast Trichosporon oleaginosus to generate non-native fatty acids and the molecular basis for the activity of the AfR•Afx system was elucidated.
Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids
TLDR
It is demonstrated that redox system engineering can boost and harmonize the catalytic efficiency of class I hydroxylase enzyme cascades and enhance the activity of the PdR·Pdx system.
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Targeted Engineering of Cyclooctat‐9‐en‐7‐ol Synthase: A Stereospecific Access to Two New Non‐natural Fusicoccane‐Type Diterpenes
The structural diversity of bioactive diterpenes is due to variations in their macrocyclic carbon skeletons. The chemical synthesis of these macrocycles is challenging. However, the bacterial…
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Stereoselective chemo-enzymatic oxidation routes for (1R,3E,7E,11S,12S)-3,7,18-dolabellatriene
TLDR
The almost quantitative 3,7,18-dolabellatriene conversion into the new, non-natural compound (1R,3E,7E,11S,12S,18R)-dolabella-3,7-diene-20-ol by hydroboration–oxidation with an enantiomeric excess of 94%, for the first time.
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Trichome Transcripts as Efficiency Control for Synthetic Biology and Molecular Farming.
TLDR
A robust method is provided for a virtually epithelial cell-free isolation of Arabidopsis trichomes and is joined with an RNA isolation protocol to perform mRNA analysis on extracts of the isolated trichome extracts using a semi-quantitative RT-PCR setup.
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Self-service device for packaged goods
Self-service device (1) for goods packs (P), for example for arrangement in the region of POS systems in supermarkets o. The like. Sales areas, wherein a plurality of in compartments (3) stockpiled…
Correlations between Google Search Volumes of COVID-19 symptoms and infections in Germany over the course of the pandemic
Correlations between the search volume of COVID-19 symptoms and case numbers were found in some countries during the first phase of the pandemic. The objective of this study is to find out whether…
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