Christian Fritz

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In this paper, we address the problem of specifying and generating preferred plans using rich, qualitative user preferences. We propose a logical language for specifying non-Markovian preferences over the evolution of states and actions associated with a plan. The semantics for our first-order preference language is defined in the situation calculus. Unlike(More)
Almost all medium- and large-scale businesses rely on electronic workflow systems to manage their business processes. A key challenge is to enable the easy re-use and modification of these workflow schemas and their piece-parts, so that they can be adapted to new business situations. This paper describes an approach for automatic construction (and thus,(More)
PURPOSE IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity has been validated in preclinical in vitro and in vivo models. We studied the activity of IPI-504 after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy in patients with advanced, molecularly defined(More)
Real-world planning problems can require search over thousands of actions and may yield a multitude of plans of differing quality. To solve such real-world planning problems, we need to exploit domain control knowledge that will prune the search space to a manageable size. And to ensure that the plans we generate are of high quality, we need to guide search(More)
ConGolog is a logical programming language for agents that is defined in the situation calculus. ConGolog agent control programs were originally proposed as an alternative to planning, but have also more recently been proposed as a means of providing domain control knowledge for planning. In this paper, we present a compiler that takes a ConGolog program(More)
Domain control knowledge (DCK) has proven effective in improving the efficiency of plan generation by reducing the search space for a plan. Procedural DCK is a compelling type of DCK that supports a natural specification of the skeleton of a plan. Unfortunately, most state-of-the-art planners do not have the machinery necessary to exploit procedural DCK. To(More)
Hadoop is the de-facto standard for big data analytics applications. Presently available schedulers for Hadoop clusters assign tasks to nodes without regard to the capability of the nodes. We propose ThroughputScheduler, which reduces the overall job completion time on a clusters of heterogeneous nodes by actively scheduling tasks on nodes based on(More)
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cancer has not been studied. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in(More)