Christian Freiburghaus

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Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved(More)
The ultimate goal in the treatment of haemophilia patients with inhibitors is to eradicate permanently the inhibitor and induce tolerance. Here we summarize our experience at the Malmö centre regarding tolerance induction according to the Malmö Treatment Model. The protocol includes immunoadsorption if needed, neutralization of inhibitor and replacement(More)
Hot (explosive) hydrogen burning or the Rapid Proton Capture Process (rp-process) occurs in a number of astrophysical environments. Novae and X-ray bursts are the most prominent ones, but accretion disks around black holes and other sites are candidates as well. The expensive and often multidimensional hydro calculations for such events require an accurate(More)
We give an overview of chemical equilibria in explosive burning and the role which neutron and/or proton separation energies play. We focus then on the rapid neutron-capture process (r-process) which encounters unstable nuclei far from beta-stability with neutron separation energies in the range 1-4 MeV. Its observable features, like the abundances, witness(More)
A 39-year-old patient, suffering from severe haemophilia B and antibodies against factor IX, has twice been treated with extracorporeal protein A-Sepharose adsorption followed by conventional substitution therapy in combination with immunosuppression (cyclophosphamide). On both occasions, separated by a 2-year interval, the same procedure was followed(More)
The feasibility of extracorporeal adsorption of 1.5-3 L plasma on protein A-Sepharose was investigated in six patients with advanced cancer. Anticoagulation with heparin was associated with respiratory distress syndrome in two patients, most likely caused by complement activation as indicated by a transient leukopenia during plasma reinfusion and appearance(More)
  • F.-K. Thielemann, F. Brachwitz, +5 authors W. R. Hix
  • 2008
Type II supernovae (SNe II) are linked to the gravitational collapse of massive stars (M>8M) at the end of their hydrostatic evolution. The resulting central hot proto-neutron star cools via neutrino emission. Neutrino opacities and transport determine the neutrino emission luminosity, which, together with the neutrino heating eeency in adjacent layers, is(More)