Christian Freiburghaus

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Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved(More)
A 39-year-old patient, suffering from severe haemophilia B and antibodies against factor IX, has twice been treated with extracorporeal protein A-Sepharose adsorption followed by conventional substitution therapy in combination with immunosuppression (cyclophosphamide). On both occasions, separated by a 2-year interval, the same procedure was followed(More)
The ultimate goal in the treatment of haemophilia patients with inhibitors is to eradicate permanently the inhibitor and induce tolerance. Here we summarize our experience at the Malmö centre regarding tolerance induction according to the Malmö Treatment Model. The protocol includes immunoadsorption if needed, neutralization of inhibitor and replacement(More)
Protein G, a bacterial cell wall protein extracted from strains of Streptococci, has been employed as a ligand in high performance liquid affinity chromatography (HPLAC) for separation of monoclonal antibodies. Examples are given of rapid high-resolution separations of rat and mouse monoclonal antibodies belonging to various subclasses. In comparison with(More)
Hot (explosive) hydrogen burning or the Rapid Proton Capture Process (rp-process) occurs in a number of astrophysical environments. Novae and X-ray bursts are the most prominent ones, but accretion disks around black holes and other sites are candidates as well. The expensive and often multidimensional hydro calculations for such events require an accurate(More)
Treatment of hemophilia patients with inhibitors is most effective if circulating levels of factor VIII (F.VIII) or factor IX (F.IX) can be obtained. This is possible not only in patients with low inhibitor concentration, but also in those with high inhibitor levels after temporary removal of the inhibitors by means of apheresis methods. Extensive plasma(More)
In the framework of our investigation to explain the nucleosynthetic origin of the correlated Ca-Ti-Cr Isotopic Anomalies in the refractory inclusion EK 1-4-1 of the Allende Meteorite,-decay properties and deformation of the nuclear shape as well as neutron capture cross sections of neutron-rich isotopes in the N=28 region have been determined. These(More)