Christian Doenecke

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BACKGROUND Despite remarkable progress in modern laboratory testing and imaging technology in recent years, diagnostic errors still occur. To assess whether diagnostic performance in a primary referral hospital improves with new diagnostic tools and algorithms, autopsy reports were analyzed over a ten-year period to monitor diagnostic errors. METHODS(More)
We describe the case of a 48-year-old patient presenting with abdominal pain with a history of cerebral ischemia due to a patent foramen ovale with heterozygous factor V mutation. Initial work-up demonstrate a significant thrombosis of the portal venous system combined with signs of portal hypertension (ascites, oesophageal varices). Ultrasound reveals no(More)
Thymidine kinase (ATP: thymidine-2′-phosphotransferase, E.C. 2.7.1.21) was demonstrated in human blood platelets. As the enzyme is bound to the organelles, it seems to be a mitochondrial isoenzyme. Due to the fact that thymidine kinase and the DNA metabolism are highly correlated, the presence of (mitochondrial) DNA in human blood platelets is most likely.(More)
We describe the case of a 19-years old patient with seizure due to severe hypoglycaemia during general practitioner consultation. Because of hyperinsulinaemic hypoglycaemia and suspected liver metastasis a neuroendocrine hormone active tumor was suspected. After liver biopsy and CT scan a neuroendocrine pancreatic tumor could be diagnosed. Afterwards(More)
Thymidine phosphorylase (thymidine: orthophosphate deoxyribosyltransferase, E.C.: 2.4.2.4.) was detected by thin layer chromatography using PEI cellulose plates in human blood platelets. At a final concentration of 5.6 × 10−5 M thymidine the enzyme activity attained 1 µMol per hour and 1011 platelets. This enzyme was mostly found in mature cells, whilst its(More)
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