Christian D Diehl

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BACKGROUND There are various treatment options available for rosacea, depending on the subtype, but treatment is still generally unsatisfactory. Some studies have reported antiparasitic and anti-inflammatory properties of Quassia amara. AIM To check the efficacy and safety of a topical gel with 4% Quassia amara extract in the treatment of various grades(More)
BACKGROUND AND PURPOSE We sought to demonstrate that tumor necrosis factor (TNF)-α, via sphingosine-1-phosphate signaling, has the potential to alter cochlear blood flow and thus, cause ischemic hearing loss. METHODS We performed intravital fluorescence microscopy to measure blood flow and capillary diameter in anesthetized guinea pigs. To measure(More)
In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. SOD is used in cosmetic products to reduce free radical damage to the skin, for example, to reduce fibrosis following radiation for breast cancer. Pruritus is one of(More)
BACKGROUND Seborrheic dermatitis (SD) is a chronic mild skin disorder with high prevalence. Various treatment options are available, including topical antifungals and anti-inflammatories. Antifungal and anti-inflammatory properties of Quassia amara have been reported. AIM To check the efficacy and safety of a topical gel with 4% Quassia amara extract and(More)
Fibrosis of the dermis and keratosis of the epidermis are frequent late complications of irradiation, this being accidental or a consequence of radiotherapy. Fibrosis is a complex tissue response whose predominasnt characteristics are massive deposition of extracellular matrix and excessive fibroblast proliferation. A perpetual cascade of cytokines has been(More)
The primary objective of the study was to evaluate the antipruritic effect of natural superoxide dismutase in the cosmetic product Sodermix cream. In this randomized intra-individual study including 15 volunteers, 14 female and one male, mean age 41 +/- 4 (range 18-66) years, the cosmetic product Sodermix cream was evaluated according to the Dermscan Group(More)
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