Christian Colin

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This paper presents the point of view of a designer about declarative modelers. First, we propose a model of this point of view. Our approach is based on the work we have done to develop some of our declarative modelers. It takes into account the main functions used by a designer in these modelers. Then, we explain also the scene-building process and we(More)
A detailed genome mapping analysis of 213,636 expressed sequence tags (EST) derived from nontumor and tumor tissues of the oral cavity, larynx, pharynx, and thyroid was done. Transcripts matching known human genes were identified; potential new splice variants were flagged and subjected to manual curation, pointing to 788 putatively new alternative splicing(More)
Diffuse infiltrating gliomas are the most common tumors of the central nervous system (CNS), naturally progressing from a lower-grade to a higher-grade malignancy. Several genetic alterations have been correlated with astrocytic tumors; however, a number of as yet unknown genes may also be involved. Therefore, we set out to search for genes that are(More)
Pheochromocytomas are catecholamine-secreting tumors that result from mutations of at least six different genes as components of distinct autosomal dominant disorders. However, there remain familial occurrences of pheochromocytoma without a known genetic defect. We describe here a familial pheochromocytoma syndrome consistent with digenic inheritance(More)
The ADAMs comprises a family of cell surface proteins with putative roles in cell-cell and/or cell-matrix interactions and in protease activities. In this work, we have examined the expression level and the methylation status of the 5' upstream region of the adhesion molecule ADAM23 in two brain tumor cell lines (A172 and T98G) as well as in three primary(More)
The main protein of the core of murine mammary tumor virus, with a molecular weight of 28,000 (p28), was solubilized by deoxycholate treatment of the virus and purified by Ultrogel ACA-54 filtration and hydroxyapatite chromatography. This protein was used as labeled antigen in a highly specific and reproducible radioimmunoassay. Organ extracts of uninfected(More)
One of the objectives in image synthesis is to create 2D-images. However, the properties of images are not usually used in the modelling process. This paper describes a work that takes into account the characteristics of images from the beginning of the design process. 3D-scenes are automatically created so that their visualisation respects the properties(More)
ACKNOWLEDGEMENTS The Research Team would like to thank the many people whose support made this project possible. We would like to express our gratitude to Dr. Eric Thompson and Dr. Ralph Espach from the Center for Naval Analyses (CNA), our client, for their assistance throughout the course of our research. The Team would also like to thank our faculty(More)
BACKGROUND The CHD7 (Chromodomain Helicase DNA binding protein 7) gene encodes a member of the chromodomain family of ATP-dependent chromatin remodeling enzymes. Mutations in the CHD7 gene are found in individuals with CHARGE, a syndrome characterized by multiple birth malformations in several tissues. CHD7 was identified as a binding partner of PBAF(More)
Homologous radioimmunoassay of human prolactin was performed and used to investigate the secretion of this pituitary hormone under normal and pathological conditions. The following data were developed in this paper: --During the menstrual cycle, prolactin levels are more elevated during ovulatory and luteal phases than during follicular phase; --During(More)
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