Christian Colin

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This paper presents the point of view of a designer about declarative modelers. First, we propose a model of this point of view. Our approach is based on the work we have done to develop some of our declarative modelers. It takes into account the main functions used by a designer in these modelers. Then, we explain also the scene-building process and we(More)
Diffuse infiltrating gliomas are the most common tumors of the central nervous system (CNS), naturally progressing from a lower-grade to a higher-grade malignancy. Several genetic alterations have been correlated with astrocytic tumors; however, a number of as yet unknown genes may also be involved. Therefore, we set out to search for genes that are(More)
Pheochromocytomas are catecholamine-secreting tumors that result from mutations of at least six different genes as components of distinct autosomal dominant disorders. However, there remain familial occurrences of pheochromocytoma without a known genetic defect. We describe here a familial pheochromocytoma syndrome consistent with digenic inheritance(More)
The ADAMs comprises a family of cell surface proteins with putative roles in cell-cell and/or cell-matrix interactions and in protease activities. In this work, we have examined the expression level and the methylation status of the 5' upstream region of the adhesion molecule ADAM23 in two brain tumor cell lines (A172 and T98G) as well as in three primary(More)
Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we(More)
One of the objectives in image synthesis is to create 2D-images. However, the properties of images are not usually used in the modelling process. This paper describes a work that takes into account the characteristics of images from the beginning of the design process. 3D-scenes are automatically created so that their visualisation respects the properties(More)
ACKNOWLEDGEMENTS The Research Team would like to thank the many people whose support made this project possible. We would like to express our gratitude to Dr. Eric Thompson and Dr. Ralph Espach from the Center for Naval Analyses (CNA), our client, for their assistance throughout the course of our research. The Team would also like to thank our faculty(More)
BACKGROUND The CHD7 (Chromodomain Helicase DNA binding protein 7) gene encodes a member of the chromodomain family of ATP-dependent chromatin remodeling enzymes. Mutations in the CHD7 gene are found in individuals with CHARGE, a syndrome characterized by multiple birth malformations in several tissues. CHD7 was identified as a binding partner of PBAF(More)
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