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  • Aberra Fura, Ashish Khanna, +9 authors Mark Kirby
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological…
  • 2009 (First Publication: 1 June 2009)
  • Saxagliptin is a potent, selective, reversible dipeptidyl peptidase 4 (DPP4) inhibitor specifically designed for extended inhibition of the DPP4 enzyme and is currently under development for theContinue Reading
  • William N. Washburn, Mark G Manfredi, +37 authors Brian J. Murphy
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2014 (First Publication: 25 September 2014)
  • Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a challenge. Our finding that a basic moiety is not required forContinue Reading
  • Xue-Qing Chen, Kevin J Stefanski, +7 authors Michael J. Hageman
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2014 (First Publication: 1 December 2014)
  • BMS-B is a highly lipophilic compound (clog P 7.72) with poor aqueous solubility (<10 ng/mL at pH 1 and 6.5). The compound exhibits low bioavailability in preclinical species when dosed as cosolventContinue Reading
  • Sandhya Mandlekar, Anne V Rose, +4 authors Punit H. Marathe
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 2007 (First Publication: 1 September 2007)
  • With the advent of polytherapy, drug interactions have become a common clinical problem. Although in vitro data are routinely used for the prediction of drug interactions, in vitro systems are notContinue Reading
  • Hongwei Zhang, Baomin Xin, Christian Caporuscio, Timothy V. Olah
  • Medicine, Chemistry
  • Rapid communications in mass spectrometry : RCM
  • 2011 (First Publication: 30 November 2011)
  • Highly sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based methods have been developed and implemented for the quantitative determination of a number of peptides underContinue Reading
    Multiplexed LC-MS/MS was first introduced into the bioanalytical laboratory to increase sample throughput at relatively low cost as multiple LC systems are connected to a single mass spectrometerContinue Reading
  • Yingru Zhang, Christian Caporuscio, +6 authors Adrienne A. Tymiak
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 2008 (First Publication: 1 November 2008)
  • The stereoselective determination of stereoisomers in biological samples provides vital information on stereospecific metabolism and pharmacokinetic profiles of the drugs. Despite the uniqueContinue Reading
  • Pratik Devasthale, Weiqi Wang, +28 authors William N. Washburn
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2015 (First Publication: 1 October 2015)
  • Non-basic azolotriazinones were explored using an empirical free brain exposures-driven approach to identify potent MCHR1 antagonists for evaluation in in vivo efficacy studies. An optimized leadContinue Reading