Christian Braun

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BACKGROUND Radiotherapy is the standard care in elderly patients with malignant astrocytoma and the role of primary chemotherapy is poorly defined. We did a randomised trial to compare the efficacy and safety of dose-dense temozolomide alone versus radiotherapy alone in elderly patients with anaplastic astrocytoma or glioblastoma. METHODS Between May 15,(More)
Due to the growing importance of alignment, compliance and manageability issues, increased attention is being paid to architectures and architecture management recently. A holistic approach to enterprise architecture requires business related and information systems related artifacts to be equally treated. This paper describes the extension of an existing(More)
Enterprise architecture supports organizational engineering in many ways. Service orientation is regarded as dominant operations model for service providers -- within and beyond IT. As a consequence, it is important to integrate service management and service orientation into enterprise architecture. This paper proposes an enterprise architecture extension(More)
The purpose of this study was to evaluate the feasibility of intravoxel incoherent motion (IVIM) imaging and its value in differentiating the histologic grade among human gliomas. The IVIM model generated parametric images for apparent diffusion coefficient ADC, slow diffusion coefficient D (or D slow), fast diffusion coefficient D* (or D fast), and(More)
The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion-weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient (D), fast diffusion coefficient (D*), and fractional perfusion-related volume (f) in patients with high-grade gliomas were generated. Maps of Fp (plasma flow),(More)
RATIONALE AND OBJECTIVES Magnetic resonance (MR) perfusion techniques and MR spectroscopy (MRS) provide specific physiological information that may allow distinction between recurrent glioma and progression from stable disease. MATERIALS AND METHODS Forty patients underwent conventional MR imaging, dynamic contrast-enhanced T1-weighted perfusion imaging,(More)
Dominated by the behavioral science approach for a long time, information systems research increasingly acknowledges design science as a complementary approach. While primarily information systems instantiations, but also constructs and models have been discussed quite comprehensively, the design of methods is addressed rarely. But methods appear to be of(More)
LBA2000 Background: In patients with MGMT-nonmethylated glioblastoma (GBM), primary chemotherapy with temozolomide (TMZ) is at best moderately effective. There is an urgent need for more effective therapies in this large subgroup of GBM. Since results of phase II trials with the antiangiogenic agent bevacizumab (BEV) +/- irinotecan (IRI) are promising in(More)
PURPOSE A randomised, open label phase III trial was conducted to evaluate efficacy of nimotuzumab, a monoclonal antibody against epidermal growth factor receptor (EGF-R) added to standard therapy for newly diagnosed glioblastoma. PATIENTS AND METHODS 149 glioblastoma patients stratified as with or without residual tumour were randomly assigned to receive(More)
Background. Between 2005 and 2012, annual sales of E-bikes in Switzerland increased from 1,792 to 52,941. This continuous and rapid transition from human-powered bicycles to an electric bicycle technology may indicate the increasing demand for low-cost transportation technology in combination with a healthy lifestyle. Material and Methods. In the present(More)