Christian Braun

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Due to the growing importance of alignment, compliance and manageability issues, increased attention is being paid to architectures and architecture management recently. A holistic approach to enterprise architecture requires business related and information systems related artifacts to be equally treated. This paper describes the extension of an existing(More)
Enterprise architecture supports organizational engineering in many ways. Service orientation is regarded as dominant operations model for service providers -- within and beyond IT. As a consequence, it is important to integrate service management and service orientation into enterprise architecture. This paper proposes an enterprise architecture extension(More)
Dominated by the behavioral science approach for a long time, information systems research increasingly acknowledges design science as a complementary approach. While primarily information systems instantiations, but also constructs and models have been discussed quite comprehensively, the design of methods is addressed rarely. But methods appear to be of(More)
Wiskott-Aldrich syndrome (WAS) is characterized by microthrombocytopenia, immunodeficiency, autoimmunity, and susceptibility to malignancies. In our hematopoietic stem cell gene therapy (GT) trial using a γ-retroviral vector, 9 of 10 patients showed sustained engraftment and correction of WAS protein (WASP) expression in lymphoid and myeloid cells and(More)
Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of human host defense. In this study, we report on two unrelated kindreds, with two patients each, who had cryptosporidial infections associated with chronic cholangitis and liver disease. Using exome and candidate gene sequencing, we identified two distinct homozygous(More)
BACKGROUND Influenza viral shedding studies provide fundamental information for preventive strategies and modelling exercises. We conducted a prospective household study to investigate viral shedding in seasonal and pandemic influenza between 2007 and 2011 in Berlin and Munich, Germany. METHODS Study physicians recruited index patients and their household(More)
Background: Influenza viral shedding studies provide fundamental information for preventive strategies and modelling exercises. We conducted a prospective household study to investigate viral shedding in seasonal and pandemic influenza between 2007 and 2011 in Berlin and Munich, Germany. Methods: Study physicians recruited index patients and their household(More)