Christian Berger

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BACKGROUND It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like fashion, including capturing, rolling, adhesion, and transmigration.(More)
Recent efforts in the automotive domain to initiate a paradigm shift from a traditional hardware-driven to a function-driven development process create new challenges to tackle. A hardware-driven variant handling mechanism will get more and more inappropriate. Instead , new concepts and methods are necessary to model and configure concrete systems. A(More)
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