Christian Berger

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The developing Drosophila brain is a well-studied model system for neurogenesis and stem cell biology. In the Drosophila central brain, around 200 neural stem cells called neuroblasts undergo repeated rounds of asymmetric cell division. These divisions typically generate a larger self-renewing neuroblast and a smaller ganglion mother cell that undergoes one(More)
BACKGROUND It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like fashion, including capturing, rolling, adhesion, and transmigration.(More)
The inappropriate activation, positioning, and recruitment of leukocytes are implicated in the pathogenesis of multiple organ failure in sepsis. Although the local anesthetic lidocaine modulates inflammatory processes, the effects of lidocaine in sepsis are still unknown. This double-blinded, prospective, randomized clinical trial was conducted to(More)
Publish/subscribe communication is a common architectural design pattern in component-based software systems used in many of today's cyber-physical systems to exchange information between distributed software components. These systems typically deal with an increased number of data transfers, with a risk of lacking resources. Our recent domain analysis for(More)
Cyber-Physical Systems (CPS) are large interconnected softwareintensive systems that influence, by sensing and actuating, the physical world. Examples are traffic management and power grids. One of the trends we observe is the need to endow such systems with the "smart" capabilities, typically in the form of selfawareness and self-adaptation, along with the(More)
BACKGROUND The synthetic cannabinoid ajulemic acid has been demonstrated to alleviate pain in patients suffering from chronic neuropathic pain. Cannabinoids interact with several molecules within the pain circuit, including a potent inhibition of voltage-gated sodium channels. In this study, we closely characterized this property on neuronal and nonneuronal(More)
Cyber-physical systems like robots and self-driving vehicles comprise complex software systems. Their software is typically realized as distributed agents that are responsible for dedicated tasks like sensor data handling, sensor data fusion, or action planning. The modular design allows a flexible deployment as well as algorithm encapsulation to exchange(More)
Establishing and mastering continuous experimentation as an instrument in the portfolio of software product managers is of growing importance resulting in continuous renewal of products for continuous user satisfaction. Product managers for purely software-based products like web-based applications found in online web-shops or smartphone apps can monitor(More)