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OBJECTIVE Autism is a complex, largely genetic psychiatric disorder. In the majority of cases, the cause of autism is not known, but there is strong evidence for a genetic etiology. To identify candidate genes, the physical mapping of balanced chromosomal aberrations is a powerful strategy, since several genes have been characterized in numerous disorders.(More)
  • Audrey Guilmatre, Christèle Dubourg, Anne-Laure Mosca, Solenn Legallic, Alice Goldenberg, Valérie Drouin-Garraud +22 others
  • 2009
CONTEXT Results of comparative genomic hybridization studies have suggested that rare copy number variations (CNVs) at numerous loci are involved in the cause of mental retardation, autism spectrum disorders, and schizophrenia. OBJECTIVES To provide an estimate of the collective frequency of a set of recurrent or overlapping CNVs in 3 different groups of(More)
A large French family including members affected by nonspecific X-linked mental retardation, with or without autism or pervasive developmental disorder in affected male patients, has been found to have a 2-base-pair deletion in the Neuroligin 4 gene (NLGN4) located at Xp22.33. This mutation leads to a premature stop codon in the middle of the sequence of(More)
—This paper presents a methodology to process airborne interferometric synthetic aperture radar (SAR) data to measure surface velocity fields (SVFs) of temperate glaciers, and applies it to data acquired over the Aletsch glacier. The first part of this paper deals with the main limitation in airborne interfero-metric SAR to retrieve reliable interferometric(More)
—Synthetic aperture radar (SAR) interferometric data offer the opportunity to measure temperate glacier surface topography and displacement. The increase of the resolution provided by the most recent SAR systems has some critical implications. For instance, a reliable estimate of the phase gradient can only be achieved by using interferogram local(More)
BACKGROUND Cognitive deterioration is a characteristic symptom of Alzheimer's disease. This deterioration is notably associated with structural changes and subsequent cell death which occur, primarily, in acetylcholine-producing neurons, progressively damaging cholinergic neurotransmission. We have reported previously that excess acetylcholinesterase (AChE)(More)
— Airborne Differential SAR Interferometry (D-InSAR) is still a challenging task when compared to the spaceborne case due to the fact that airborne platforms are unable to describe a stable flight track. For that reason a very precise motion compensation which includes the correction of topographic-induced phase errors has to be performed in the airborne(More)
— This paper deals with the methodology in the processing of airborne SAR data to measure glacier displacement fields. The possibility to retrieve a 2D displacement map of the deformation in slant-range geometry with an airborne platform is discussed. A new extended multisquint approach is proposed to simultaneously estimate residual motion errors and the(More)
The TanDEM-X mission has the goal to deliver a digital elevation model (DEM) that fulfils HRTI-3 quality requirements on a global scale. The interferometric height is determined by the phase difference between the two acquired images and the spatial geometry. Baseline errors intrinsic of the bi-static SAR configuration combined with errors and drifts of the(More)
The oligodendrocyte myelin glycoprotein (OMgp) is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). Although the precise function of OMgp is yet to be determined in vivo, recent in vitro studies suggested roles for this protein in both the developing and adult central nervous(More)