Christian A. Tiemann

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MOTIVATION To further our understanding of the mechanisms underlying biochemical pathways mathematical modelling is used. Since many parameter values are unknown they need to be estimated using experimental observations. The complexity of models necessary to describe biological pathways in combination with the limited amount of quantitative data results in(More)
MOTIVATION Systems biology employs mathematical modelling to further our understanding of biochemical pathways. Since the amount of experimental data on which the models are parameterized is often limited, these models exhibit large uncertainty in both parameters and predictions. Statistical methods can be used to select experiments that will reduce such(More)
BACKGROUND The study of phenotype transitions is important to understand progressive diseases, e.g., diabetes mellitus, metabolic syndrome, and cardiovascular diseases. A challenge remains to explain phenotype transitions in terms of adaptations in molecular components and interactions in underlying biological systems. RESULTS Here, mathematical modeling(More)
The field of medical systems biology aims to advance understanding of molecular mechanisms that drive disease progression and to translate this knowledge into therapies to effectively treat diseases. A challenging task is the investigation of long-term effects of a (pharmacological) treatment, to establish its applicability and to identify potential side(More)
Mathematical modeling is often used to formalize hypotheses on how a biochemical network operates by discriminating between competing models. Bayesian model selection offers a way to determine the amount of evidence that data provides to support one model over the other while favoring simple models. In practice, the amount of experimental data is often(More)
Metabolic profiling in combination with pathway-based analyses and computational modelling are becoming increasingly important in clinical and preclinical research. Modelling multi-factorial, progressive diseases requires the integration of molecular data at the metabolome, proteome and transcriptome levels. Also the dynamic interaction of organs and(More)
A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism This text provides additional information regarding the build-up of the lipoprotein grids. It consists of (a) a more detailed derivation and argumentation of equation (3) (Main Text), (b) the derivation and application of the(More)
Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are considered to be disease risk markers. However, the measured profile is a collective result of complex metabolic interactions, which complicates the identification of changes in(More)
A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism Following parameter estimation and evaluation, two parameter sets were found to describe the data well (these will be referred to as sets X1 and X2). Inspection of the in silico FPLC profiles (e.g. Figure 1 in Text S4)(More)
A computational model for the analysis of lipoprotein distributions in the mouse: Translating FPLC profiles to lipoprotein metabolism This text provides the mathematical description of the ordinary differential equations and boundary conditions-first an overview of the governing differential equations, followed by more detailed descriptions of the(More)