Christian A. Kortleven

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Presynaptic cannabinoid (CB1R) and metabotropic glutamate receptors (mGluR2/3) regulate synaptic strength by inhibiting secretion. Here, we reveal a presynaptic inhibitory pathway activated by extracellular signal-regulated kinase (ERK) that mediates CB1R- and mGluR2/3-induced secretion inhibition. This pathway is triggered by a variety of events, from foot(More)
Individual cortical layers have distinct roles in information processing. All layers receive cholinergic inputs from the basal forebrain (BF), which is crucial for cognition. Acetylcholinergic receptors are differentially distributed across cortical layers, and recent evidence suggests that different populations of BF cholinergic neurons may target specific(More)
Presynaptic inhibition upon CB1 and mGluR2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1 Sabine K. Schmitz, Cillian King, Christian Kortleven, Vincent Huson, Tim Kroon, Josta T. Kevenaar, Desiree Schut, Ingrid Saarloos, Joost P. Hoetjes, Heidi de Wit, Oliver Stiedl, Sabine Spijker, Ka Wan Li, Huibert D. Mansvelder, August B. Smit,(More)
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