Christer Sylven

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OBJECTIVES In the Euroinject One phase II randomized double-blind trial, therapeutic angiogenesis of percutaneous intramyocardial plasmid gene transfer of vascular endothelial growth factor (phVEGF-A(165)) on myocardial perfusion, left ventricular function, and clinical symptoms was assessed. BACKGROUND Evidence for safety and treatment efficacy have been(More)
To compare two situations with similar magnitudes of mitochondrial substrate flux but different blood oxygen contents, one-legged training was employed. Ten healthy subjects trained one leg under normobaric conditions and the other under hypobaric conditions. At each session the subjects trained each leg for 30 min. The absolute work intensity was the same(More)
Differences between the effects of training at sea level and at simulated altitude on performance and muscle structural and biochemical properties were investigated in 8 competitive cyclists who trained for 3–4 weeks, 4–5 sessions/week, each session consisting of cycling for 60–90 min continuously and 45–60 min intermittently. Four subjects, the altitude(More)
The aim of the present study was to compare males and females with similar training backgrounds regarding the relationship between anaerobic performance and muscle characteristics and to test whether any of the analysed expressions of muscle characteristics could predict some of the difference in anaerobic performance between sexes. Subjects performed 30 s(More)
The purpose of this study was to determine if changes in intra-muscular myoglobin concentration accompany histochemical and enzymatic adaptations to supra-maximal exercise training. Subjects were assigned to either a training group (N = 11), who trained 2 to 3 times weekly for 6 wk, or a control group (N = 6). Training progressed from two 15-s and two 30-s(More)
OBJECTIVE This study investigates whether local sequential delivery of vascular endothelial growth factor-A(165) (VEGF-A(165)) followed by platelet-derived growth factor-BB (PDGF-BB) with alginate hydrogels could induce an angiogenic effect and functional improvement greater than single factors after myocardial infarction. METHODS Alginate hydrogels were(More)
BACKGROUND Cardiac creatine levels are depressed in chronic heart failure. Oral supplementation of creatine to healthy volunteers has been shown to increase physical performance. AIM To evaluate the effects of creatine supplementation on ejection fraction, symptom-limited physical endurance and skeletal muscle strength in patients with chronic heart(More)
OBJECTIVES To study non-linear complexity or chaotic behaviour of heart rate in short time series and its dependence on autonomic tone. METHODS Ten healthy individuals (5 men, mean age 44 years) were investigated at rest, after intravenous injections of propranolol (0.15 mg/kg), followed by atropine (0.03 mg/kg). On another occasion, investigation was(More)
Recent studies have suggested that human embryonic stem cells (HESC) are immune-privileged and may thereby circumvent rejection. The expression of immunologically active molecules was studied by DNA microarray analysis and by flow cytometry. HESC were transplanted into immunologically competent mice and traced by fluorescence in-situ hybridization (FISH)(More)
An overall procedure for the determination of myoglobin in muscle biopsy specimens by a radioimmunoassay is described. The coefficient of variation in routine analysis averaged 18%. The mean myoglobin content in leg skeletal muscle of 13 females and 18 males was 4.7 mg/g wet weight. There were no sex differences but the levels for elderly subjects (56-80(More)