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The Apollo 5′ Exonuclease Functions Together with TRF2 to Protect Telomeres from DNA Repair
- Christelle Lenain, S. Bauwens, Simon Amiard, M. Brunori, M. Giraud-Panis, E. Gilson
- Medicine, Biology
- Current Biology
- 11 July 2006
A major issue in telomere research is to understand how the integrity of chromosome ends is preserved . The human telomeric protein TRF2 coordinates several pathways that prevent checkpoint… Expand
A topological mechanism for TRF2-enhanced strand invasion
- Simon Amiard, M. Doudeau, +10 authors M. Giraud-Panis
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 February 2007
Telomeres can fold into t-loops that may result from the invasion of the 3′ overhang into duplex DNA. Their formation is facilitated in vitro by the telomeric protein TRF2, but very little is known… Expand
TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage
Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5' exonuclease activity of its binding… Expand
Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.
- Christelle Lenain, C. D. de Graaf, +6 authors D. Peeper
- Biology, Medicine
- Genome research
- 1 October 2017
Cellular senescence is a mechanism that virtually irreversibly suppresses the proliferative capacity of cells in response to various stress signals. This includes the expression of activated… Expand
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence.
- Christelle Lenain, Olga Gusyatiner, Sirith Douma, B. van den Broek, D. Peeper
- Chemistry, Medicine
- 1 November 2015
Cellular senescence is a largely irreversible form of cell cycle arrest triggered by various types of damage and stress, including oncogene expression (termed oncogene-induced senescence or OIS). We… Expand
Second autologous transplantation after failure of a first autologous transplant in 18 patients with non-Hodgkin's lymphoma.
- Christelle Lenain, C. Dumontet, +6 authors J. Blay
- The hematology journal : the official journal of…
High-dose chemotherapy and autologous marrow or peripheral stem cell support offers the best chance of cure in some subgroups of patients with non-Hodgkin's lymphoma (NHL). Less is known about the… Expand
[Targeting telomeres to enforce cancer cells to senesce].
The telomeres protect the end of chromosomes from being recognized and processed as an accidental double stranded break. In human somatic cells, telomeres shorten progressively with every round of… Expand
Phase Ib/II open-label, randomized evaluation of efficacy and safety of atezolizumab plus isatuximab versus regorafenib in MORPHEUS-colorectal cancer.
82Background: The MORPHEUS platform consists of multiple, global, open-label, randomized Phase Ib/II trials designed to identify early efficacy signals and safety of treatment (tx) combinations acr...
Monitoring UV‐induced signalling pathways in an ex vivo skin organ culture model using phospho‐antibody array
- Christelle Lenain, Bastien Gamboa, +6 authors B. Méhul
- Biology, Medicine
- Experimental dermatology
- 1 May 2018
We investigated UV‐induced signalling in an ex vivo skin organ culture model using phospho‐antibody array. Phosphorylation modulations were analysed in time‐course experiments following exposure to… Expand
Abstract 1266: Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence
Cellular senescence is a stable form of cell cycle arrest triggered by a variety of damages and stresses including oncogene expression (oncogene-induced senescence or OIS). We and others previously… Expand