How adherent and contractile systems coordinate to promote cell shape changes is unclear. Here, we define a counterbalanced adhesion/contraction model for cell shape control. Live-cell microscopy data showed a crucial role for a contractile meshwork at the top of the cell, which is composed of actin arcs and myosin IIA filaments. The contractile actin… (More)
See also Weisel JW. Biomechanics in hemostasis and thrombosis. This issue, pp 1027-9; Liu W, Carlisle CR, Sparks EA, Guthold M. The mechanical properties of single fibrin fibers. This issue, pp 1030-6.