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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
TLDR
A novel class of methylated H3K4 effector domains—the PHD domains of the ING (for inhibitor of growth) family of tumour suppressor proteins—are identified and established a pivotal role for trimethylation of H 3K4 in gene repression and, potentially, tumour suppressing mechanisms. Expand
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
TLDR
Since INGs, HBO1, and MOZ/MORF contribute to oncogenic transformation, the multisubunit assemblies characterized here underscore the critical role of epigenetic regulation in cancer development. Expand
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.
TLDR
It is shown that in both species most CpG islands (CGI) contain Oris, although methylation is nearly absent in Drosophila, indicating that this epigenetic mark is not crucial for defining the activated origin. Expand
A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16
TLDR
It is found that reduction in the levels of hMSLs and acetylation of H4 at lysine 16 are correlated with reduced transcription of some genes and with a G2/M cell cycle arrest. Expand
MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair
TLDR
It is proposed that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair, and greatly decreased DNA double-strand break repair by both NHEJ and homologous recombination. Expand
Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes
TLDR
Findings indicate that BRPF proteins play a key role in assembling and activating MOZ/MORF acetyltransferase complexes and enhances the transcriptional potential of MOZ and a leukemic MOZ-TIF2 fusion protein. Expand
The chromatin environment shapes DNA replication origin organization and defines origin classes.
TLDR
These data demonstrate that specific chromatin landscapes and combinations of specific signatures regulate origin localization and suggest that in multicellular eukaryotes, the combination of distinct genetic features and chromatin configurations act in synergy to define and adapt the origin profile. Expand
New insights into replication origin characteristics in metazoans
TLDR
Bioinformatic analyses showing that the previously identified GC-rich sequence elements form origin G-rich repeated elements (OGREs) that are present in 67% to 90% of the DNA replication origins from Drosophila to human cells, respectively and initiation of DNA synthesis takes place precisely at 160 bp and 280 bp from the OGRE. Expand
Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation
TLDR
It is shown that natively regulated association of the ING4/5 PHD domain with HBO1-JADE determines the growth inhibitory function of the complex, linked to its tumor suppressor activity. Expand
HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.
The HBO1 HAT protein is the major source of histone H4 acetylation in vivo and has been shown to play critical roles in gene regulation and DNA replication. A distinctive characteristic of HBO1 HATExpand
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