Christeene G. Haj

  • Citations Per Year
Learn More
Cannabidiol (CBD) is a component of cannabis, which does not cause the typical marijuana-type effects, but has a high potential for use in several therapeutic areas. In contrast to Δ(9)-tetrahydrocannabinol (Δ(9)-THC), it binds very weakly to the CB1 and CB2 cannabinoid receptors. It has potent activity in both in vitro and in vivo anti-inflammatory assays.(More)
Cannabidiol (CBD), the non-psychoactive cannabinoid, has been previously shown by us to decrease peripheral inflammation and neuroinflammation in mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Here we have studied the anti-inflammatory effects of newly synthesized derivatives of natural (-)-CBD(More)
Cannabidiol (CBD) is a major Cannabis sativa constituent, which does not cause the typical marijuana psychoactivity. However, it has been shown to be active in a numerous pharmacological assays, including mice tests for anxiety, obsessive-compulsive disorder, depression and schizophrenia. In human trials the doses of CBD needed to achieve effects in anxiety(More)
The first step of Fig 2 appears erroneously in the publication as a repetition of Fig 1. The correct Fig 2 should show the oxidation of cannabidiol diacetate to 9-hydroxy-cannabidiol diacetate. Please see the correct Fig 2 here. Copyright: © 2016 Breuer et al. This is an open access article distributed under the terms of the Creative Commons Attribution(More)
Cannabidiol (CBD) is a component of cannabis, which does not cause the typical marijuana-type effects, but has a high potential for use in several therapeutic areas. In contrast to Δ-tetrahydrocannabinol (Δ-THC) it binds very weakly to the CB1 and CB2 cannabinoid receptors. It has potent activity in both in vitro and in vivo antiinflammatory assays. Thus,(More)
BACKGROUND AND PURPOSE To compare the abilities of cannabidiolic acid methyl ester (HU-580) and cannabidiolic acid (CBDA) to enhance 5-HT1A receptor activation in vitro and to produce 5-HT1A -mediated reductions of nausea and anxiety in vivo. EXPERIMENTAL APPROACH We investigated the effects of HU-580 and CBDA on (i) activation by(More)
  • 1