Christal Mah

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Binding of 3beta-(4-iodophenyl) tropane-2beta-carboxylic acid methyl ester ([125I]RTI-55) to the dopamine transporter (DAT) in neostriatum from C57BL/6J, DBA/2J, and 21 BXD recombinant inbred (RI) mouse strains indicated highly significant strain differences in DAT density (Bmax) but no significant differences in affinity (Kd) for this radioligand. Strain(More)
TITLE: PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioural and biochemical abnormalities in an amphetamine-sensitized preclinical model of schizophrenia ABSTRACT Allosteric modulators are emerging as a new class of therapeutics for the treatment of complex disorders, including psychiatric illnesses such as(More)
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