Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

• Ernestina Schipani, Christa Maes, Geert Carmeliet, Gregg L Semenza
• Journal of bone and mineral research : the…
• 2009

Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis in bone are… (More)

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.

• Christa Maes, Ingrid Stockmans, +5 authors Geert Carmeliet
• The Journal of clinical investigation
• 2004

VEGF is crucial for metaphyseal bone vascularization. In contrast, the angiogenic factors required for vascularization of epiphyseal cartilage are unknown, although this represents a developmentally… (More)

Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

• Christa Maes, Peter Carmeliet, +5 authors Geert Carmeliet
• Mechanisms of Development
• 2002

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is an important part of bone formation. To clarify the role of VEGF isoforms in endochondral bone formation, we examined long bone… (More)

Hypoxia-driven pathways in bone development, regeneration and disease

• Christa Maes, Geert Carmeliet, Ernestina Schipani
• Nature Reviews Rheumatology
• 2012

Adaptation to hypoxia is a critical cellular event both in pathological settings, such as cancer and ischaemia, and in normal development and differentiation. Oxygen is thought to be not only an… (More)

VEGF: A modifier of the del22q11 (DiGeorge) syndrome?

• Ingeborg Stalmans, Diether Lambrechts, +29 authors Peter Carmeliet
• Nature Medicine
• 2003

Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely… (More)

Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts.

• Ritsuko Masuyama, Ingrid Stockmans, +5 authors Geert Carmeliet
• The Journal of clinical investigation
• 2006

Genomic actions induced by 1alpha25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] are crucial for normal bone metabolism, mainly because they regulate active intestinal calcium transport. To evaluate… (More)

Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.

• Christa Maes, Steven Goossens, +17 authors Jody J. Haigh
• The EMBO journal
• 2010

Vascular endothelial growth factor (VEGF) and beta-catenin both act broadly in embryogenesis and adulthood, including in the skeletal and vascular systems. Increased or deregulated activity of these… (More)

Disorders of calcium homeostasis.

• Geert Carmeliet, Sophie Van Cromphaut, Evis Daci, Christa Maes, R Bouillon
• Best practice & research. Clinical endocrinology…
• 2003

To ensure a multitude of essential cellular functions, the extracellular concentration of calcium is maintained within a narrow physiological range. This depends on integrated regulation of calcium… (More)

Role and Regulation of Vascularization Processes in Endochondral Bones

• Christa Maes
• Calcified Tissue International
• 2012

Adequate vascularization is an absolute requirement for bone development, growth, homeostasis, and repair. Endochondral ossification during fetal skeletogenesis is typified by the initial formation… (More)

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair.

• Christa Maes, Lieve Coenegrachts, +10 authors Geert Carmeliet
• The Journal of clinical investigation
• 2006

Current therapies for delayed- or nonunion bone fractures are still largely ineffective. Previous studies indicated that the VEGF homolog placental growth factor (PlGF) has a more significant role in… (More)

• ‹
• 1
• 2
• ›