Learn More
The automated generation of timing models from gate-level netlists facilitates IP reuse and dramatically improves chip-level STA runtime in a hierarchical design flow. In this paper we discuss two different approaches to model generation, the design flows they lend themselves to and results from the application of these model generation solutions to large(More)
We have monitored oscillations in arterial pH (of respiratory frequency) in normal man at rest and during exercise. The pH oscillations are known to reflect respiratory oscillations in arterial carbon dioxide tension generated at the lungs. We have found that the pH oscillations increase in their upslope and downslope during exercise. This means that(More)
BACKGROUND Outbreaks of poliomyelitis in African countries that were previously free of wild-type poliovirus cost the Global Polio Eradication Initiative US$850 million during 2003-2009, and have limited the ability of the program to focus on endemic countries. A quantitative understanding of the factors that predict the distribution and timing of outbreaks(More)
BACKGROUND The eradication of wild-type polioviruses in areas with efficient fecal-oral transmission relies on intestinal mucosal immunity induced by oral poliovirus vaccine (OPV). Mucosal immunity is thought to wane over time but the rate of loss of protection has not been examined. METHODS We examined the degree and duration of intestinal mucosal(More)
BACKGROUND In 2009, enhanced poliovirus surveillance was established in polio-endemic areas of Uttar Pradesh and Bihar, India, to assess poliovirus infection in older individuals. METHODS In Uttar Pradesh, stool specimens from asymptomatic household and neighborhood contacts of patients with laboratory-confirmed polio were tested for polioviruses. In(More)
Acetazolamide is the standard carbonic anhydrase (CA) inhibitor used for acute mountain sickness (AMS), however some of its undesirable effects are related to intracellular penetrance into many tissues, including across the blood-brain barrier. Benzolamide is a much more hydrophilic inhibitor, which nonetheless retains a strong renal action to engender a(More)
The new year and new semester are well underway. The customary scramble that accompanies the beginning of every semester has now settled into normal hustle of academia. Preparations for the next journey have begun while keeping today's quest on track. There are papers to write, papers to read, papers to present; applications to complete; research to conduct(More)