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Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique serine in eIF2α. This collection of signaling pathways is termed the 'integrated stress response'(More)
We have developed highly modular middleware for robotics programming and an interface for multi-robot teleoperation. WURDE provides abstractions for the communications, applications , and systems levels of robotic system development, which helps to isolate the developer from details not essential to the immediate task. RIDE is a control interface inspired(More)
Much research aimed at discovering the genetic bases of longevity focuses on the budding yeast Saccharomyces cerevisiae. Unfortunately, yeast researchers use a definition of longevity not applied to other species. We propose here a method that makes it possible to estimate for yeast the same measures of longevity calculated for other species. We also show(More)
This paper describes our experience applying formal verification to the cache coherence protocol of the HAL S1 System , a shared-memory and/or message-passing multipro-cessor consisting of standard Intel Pentium R Pro symmetric multiprocessing (SMP) servers connected by HAL's proprietary Mercury Interconnect to create a cache-coherent, non-uniform memory(More)
This paper presents an algorithm for hardware verification that uses simulation and satisfiability checking techniques to determine the correctness of a symbolic test case on a circuit. The goal is to have coverage greater than that of random testing, but with the ease of use and predictability of directed testing. The user uses symbolic variables in simple(More)
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for these diseases, but are mainly effective against the microfilarial stage and have minimal or no effect on(More)
In social interactions, the appropriate timing of physical actions is of vital importance. Otherwise appropriate actions performed at the wrong time can completely alter their perceived meaning. In this paper, we propose an approach to developing a physical vocabulary for human-robot interaction that uses trained actors as models of appropriate timing and(More)
BACKGROUND Standard care for the rehabilitation of knee conditions involves exercise programs and information provision. Current methods of rehabilitation delivery struggle to keep up with large volumes of patients and the length of treatment required to maximize the recovery. Therefore, the development of novel interventions to support self-management is(More)