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With the ubiquity of multicore computing, and the likely expansion of it, it seems irresponsible for constraints researchers to ignore the implications of it. Therefore, the authors have recently begun investigating the literature in constraints on exploitation of parallel systems for constraint solving. We have been compiling an incomplete, biased, and(More)
Two series of (N-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3 beta-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and alpha 2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity(More)
We present a specialised binary constraint for the stable marriage problem. This constraint acts between a pair of integer variables where the domains of those variables represent preferences. Our constraint enforces stability and disallows bigamy. For a stable marriage instance with n men and women we require n 2 of these constraints, and the complexity of(More)
Primary cultures of bovine adrenal medullary chromaffin cells were used to study the regulation of opioid peptide (OP) synthesis. Chromaffin cells continuously exposed to tetrabenazine, a drug that depletes cellular catecholamine stores, increase their OP contents between 32 hr and 6 days of treatment. At no time following tetrabenazine addition were(More)
Cyclic AMP formation was found to increase in mouse neuroblastoma N18TG2 cells exposed to 5-hydroxytryptamine (5-HT). This response was concentration-dependent with an EC50 value of 0.22 microM. Tryptamine and other tryptamine-related compounds were also agonists in this assay with a rank order of potency of 5-methoxytryptamine > 5-HT > tryptamine >(More)
[18F]4-Fluorobenzyl iodide ([18F]FBI) was prepared, and a series of model alkylation studies were conducted to determine its chemical reactivity toward nitrogen and sulfur nucleophiles of varying nucleophilicities. [18F]FBI was found to react rapidly with secondary amines and anilines to give the corresponding N-[18F]4-fluorobenzyl analogue in high yield.(More)
The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephalin-like IR detected in tissue extracts(More)
A constraint programming approach to the hospitals / residents problem. Abstract. An instance I of the Hospitals / Residents problem (HR) involves a set of residents (graduating medical students) and a set of hospitals, where each hospital has a given capacity. The residents have preferences for the hospitals, as do hospitals for residents. A solution of I(More)
This paper introduces a problem called the temporal knapsack problem, presents several algorithms for solving it, and compares their performance. The temporal knapsack problem is a generalisation of the knapsack problem and specialisation of the multidimensional (or multiconstraint) knapsack problem. It arises naturally in applications such as allocating(More)