Chris Unsworth

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With the ubiquity of multicore computing, and the likely expansion of it, it seems irresponsible for constraints researchers to ignore the implications of it. Therefore, the authors have recently begun investigating the literature in constraints on exploitation of parallel systems for constraint solving. We have been compiling an incomplete, biased, and(More)
Two series of (N-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3 beta-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and alpha 2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity(More)
Although the exocytotic mechanism for quantal acetylcholine (ACh) release has been widely accepted for many years, it has repeatedly been challenged by reports that ACh released upon stimulation originates from the cytosol rather than synaptic vesicles. In this report, two independent experimental approaches were taken to establish the source of ACh(More)
This paper introduces a problem called the temporal knapsack problem, presents several algorithms for solving it, and compares their performance. The temporal knapsack problem is a generalisation of the knapsack problem and specialisation of the multidimensional (or multiconstraint) knapsack problem. It arises naturally in applications such as allocating(More)
Harvey and Ginsberg's limited discrepancy search (LDS) is based on the assumption that costly heuristic mistakes are made early in the search process. Consequently, LDS repeatedly probes the state space, going against the heuristic (i.e., taking discrepancies) a specified number of times in all possible ways and attempts to take those discrepancies as early(More)
The density of 5-hydroxytryptamine (5-HT)1B receptors and their coupling to the inhibition of cAMP accumulation were investigated in opossum kidney cells maintained in culture. The density and properties of the receptor were determined using [125I] iodocyanopindolol as the radioligand. The pharmacological specificity of the binding site was consistent with(More)
The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephalin-like IR detected in tissue extracts(More)
Cyclic AMP formation was found to increase in mouse neuroblastoma N18TG2 cells exposed to 5-hydroxytryptamine (5-HT). This response was concentration-dependent with an EC50 value of 0.22 microM. Tryptamine and other tryptamine-related compounds were also agonists in this assay with a rank order of potency of 5-methoxytryptamine > 5-HT > tryptamine >(More)