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For people travelling using public transport, overcrowding is one of the major causes of discomfort. However, most Advanced Traveller Information Systems (ATIS) do not take crowdedness into account, suggesting routes either based on number of interchanges or overall travel time, regardless of how comfortable (in terms of crowdedness) the trip might be.(More)
Herpes simplex virus (HSV)-derived vectors have been suggested for potential use in gene therapy for Parkinson's disease (PD). HSV naturally infects adult neuronal cells and possesses a large genome for the insertion of transgenes. In the present study, we have used two different HSV constructs to deliver glial cell line-derived neurotrophic factor (GDNF)(More)
UNLABELLED BACKGROUND1471-2229-9-51: American chestnut (Castanea dentata) was devastated by an exotic pathogen in the beginning of the twentieth century. This chestnut blight is caused by Cryphonectria parasitica, a fungus that infects stem tissues and kills the trees by girdling them. Because of the great economic and ecological value of this species,(More)
We have used the annotations of six animal genomes (Homo sapiens, Mus musculus, Ciona intestinalis, Drosophila melanogaster, Anopheles gambiae, and Caenorhabditis elegans) together with the sequences of five unannotated Drosophila genomes to survey changes in protein sequence and gene structure over a variety of timescales--from the less than 5 million(More)
Multiple sequence alignment of distantly related viral proteins remains a challenge to all currently available alignment methods. The hidden Markov model approach offers a new, flexible method for the generation of multiple sequence alignments. The results of studies attempting to infer appropriate parameter constraints for the generation of de novo HMMs(More)
expand the use of distributed computer infrastructures as well as facilitate grid interoperability, OGSA has developed standards and specifications that address a range of scenarios, including high-throughput computing, federated data management, and service mobility. G rid computing 1-3 involves the virtualization, integration, and management of services(More)
SUMMARY After seven years of life the Open Grid Forum (OGF), previously the Global Grid Forum, is beginning to produce standards that meet the needs of the community and that are being adopted by commercial and open source software providers. Accessing computational resources, specifically high performance computing (HPC) resources, is a usage scenario that(More)