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For people travelling using public transport, overcrowding is one of the major causes of discomfort. However, most Advanced Traveller Information Systems (ATIS) do not take crowdedness into account, suggesting routes either based on number of interchanges or overall travel time, regardless of how comfortable (in terms of crowdedness) the trip might be.(More)
We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow-derived cell type that stimulates the proliferation and ultimate deletion of self-reactive CD8 T cells. This process has been referred to as cross-tolerance. Here, we characterize the(More)
Multiple sequence alignment of distantly related viral proteins remains a challenge to all currently available alignment methods. The hidden Markov model approach offers a new, flexible method for the generation of multiple sequence alignments. The results of studies attempting to infer appropriate parameter constraints for the generation of de novo HMMs(More)
Localized cutaneous herpes simplex virus type 1 (HSV-1) infection leads to arming and initial expansion of cytotoxic T lymphocytes (CTLs) in the draining popliteal lymph nodes (PLNs) followed by migration and further proliferation in the spleen. To accurately characterize the sequence of events involved in the activation and generation of anti-HSV CTLs, we(More)
expand the use of distributed computer infrastructures as well as facilitate grid interoperability, OGSA has developed standards and specifications that address a range of scenarios, including high-throughput computing, federated data management, and service mobility. G rid computing 1-3 involves the virtualization, integration, and management of services(More)
SUMMARY After seven years of life the Open Grid Forum (OGF), previously the Global Grid Forum, is beginning to produce standards that meet the needs of the community and that are being adopted by commercial and open source software providers. Accessing computational resources, specifically high performance computing (HPC) resources, is a usage scenario that(More)
This paper introduces SOAR, a service-oriented architecture for the real-estate industry that embeds trust and security , allows for formal correctness proofs of service interactions , and systematically addresses human interaction capabilities through web-based user access to services. We demonstrate the features of SOAR through a DealMaker service that(More)
Herpes simplex virus (HSV)-derived vectors have been suggested for potential use in gene therapy for Parkinson's disease (PD). HSV naturally infects adult neuronal cells and possesses a large genome for the insertion of transgenes. In the present study, we have used two different HSV constructs to deliver glial cell line-derived neurotrophic factor (GDNF)(More)