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— Defense in depth is a common strategy that uses layers of firewalls to protect Supervisory Control and Data Acquisition (SCADA) subnets and other critical resources on enterprise networks. A tool named NetSPA is presented that analyzes firewall rules and vulnerabilities to construct attack graphs. These show how inside and outside attackers can progress(More)
The course of homelessness was examined among adults entering treatment in the Chicago Target Cities sample, which was aimed at improving the service delivery system in large metropolitan areas across the U.S. The objectives of the present study were: (1) Examine transitions in and out of homelessness over 3 years post entry into treatment; and (2)(More)
1 Development Bank .The views expressed are not necessarily those of the Bank or its board of directors. The authors would like to thank de Barros for kindly providing data. Please address comments to miguels@iadb.org. Abstract: This work assesses the changes in aggregate poverty and inequality that have taken place in Latin America during the past 26(More)
An external quality assessment (EQA) panel consisting of a total of 13 samples in broncho alveolar lavage (BAL) or transport medium was prepared to assess the proficiency of laboratories in the correct detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae by nucleic acid amplification techniques (NAATs) (6 samples containing various concentrations(More)
The type I interferon system is integral to human antiviral immunity. However, inappropriate stimulation or defective negative regulation of this system can lead to inflammatory disease. We sought to determine the molecular basis of genetically uncharacterized cases of the type I interferonopathy Aicardi-Goutières syndrome and of other undefined(More)
INTRODUCTION Breaching the skin's stratum corneum barrier raises the possibility of the administration of vaccines, gene vectors, antibodies and even nanoparticles, all of which have at least their initial effect on populations of skin cells. AREAS COVERED Intradermal vaccine delivery holds enormous potential for improved therapeutic outcomes for(More)
Homeostasis in the intact organism is achieved implicitly by repeated incremental feedback (inhibitory) and feedforward (stimulatory) adjustments enforced via intermittent signal exchange. In separated systems, neurohormone signals act deterministically on target cells via quantifiable effector-response functions. On the other hand, in vivo interglandular(More)
University. This 'issues paper' was generated through a 'virtual workshop process' over the course of several months. The authors first outlined relevant issues and key literature. A draft was then distributed , comments were received, and a revised draft was circulated among authors for approval. The use of a 'virtual workshop process' shaped both the tone(More)
BACKGROUND Rheumatic diseases in children are associated with significant morbidity and poor health-related quality of life (HRQOL). There is no health-related quality of life (HRQOL) scale available specifically for children with less common rheumatic diseases. These diseases share several features with systemic lupus erythematosus (SLE) such as their(More)
The density of reactive carboxyl groups on the surface of poly(lactide-co-glycolide) (PLGA) nanoparticles (NP) was modulated using a combination of high-molecular weight (MW) encapped and low MW non-encapped PLGA. Carboxyl groups were activated using carbodiimide chemistry and conjugated to bovine serum albumin and a model polyclonal antibody. Activation of(More)