Chris Petropoulos

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HER2 is gene amplified or over-expressed in 20–25% of breast cancers resulting in elevated HER2 activation. Trastuzumab (Herceptin), a humanized monoclonal antibody, targets activated HER2 and is clinically effective in HER2-over-expressing breast cancers. However, despite prolonged survival, treated breast cancer patients develop resistance. Resistance to(More)
Differences in baseline polymorphisms between subtypes may result in development of diverse mutational pathways during antiretroviral treatment. We compared drug resistance in patients with human immunodeficiency virus subtype C (referred to herein as "subtype-C-infected patients") versus subtype-B-infected patients following protease inhibitor (PI)(More)
BACKGROUND A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against the vaccine antigens. Here we assessed the magnitude and breadth of neutralizing antibody responses in Vax004. METHODS Neutralizing(More)
Human immunodeficiency virus type 1 (HIV-1) Gag protease cleavage sites (CS) undergo sequence changes during the development of resistance to several protease inhibitors (PIs). We have analyzed the association of sequence variation at the p7/p1 and p1/p6 CS in conjunction with amprenavir (APV)-specific protease mutations following PI combination therapy(More)
ANN D. KWONG,* ISABEL NAJERA, JILL BECHTEL, SCOTT BOWDEN, JOSEPH FITZGIBBON, PATRICK HARRINGTON, DALE KEMPF,** TARA L. KIEFFER,* DIANA KOLETZKI, GEORGE KUKOLJ, SHARLENE LIM, TAMI PILOT–MATIAS,** KAI LIN, NINA MANI, HONGMEI MO,*** JULES O’REAR, MICHAEL OTTO, NEIL PARKIN, JEAN–MICHEL PAWLOTSKY, CHRIS PETROPOULOS, GASTON PICCHIO, ROBERT RALSTON,**** JACQUELINE(More)
BACKGROUND The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine development, as it has the necessary attribute of being able to elicit antibodies capable of(More)
Tourism demand forecasts are of great economic value both for the public and private sector. Any information concerning the future evolution of tourism flows, is of great importance to hoteliers, tour operators and other industries concerned with tourism or transportation, in order to adjust their policy and corporate finance. In the last few decades,(More)
Integrin receptors mediate interaction between the cellular actin-cytoskeleton and extracellular matrix. Based on their activation properties, we propose a reaction-diffusion model where the kinetics of the two-state receptors is modulated by their lipidic environment. This environment serves as an activator variable, while a second variable plays the role(More)
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