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Optical coherence tomography (OCT) is an emerging medical imaging technology that can generate high resolution, cross-sectional images of tissue in situ and in real time. Although endoscopic OCT has been used successfully to identify certain pathologies in the gastrointestinal tract, the resolution of current endoscopic OCT systems has been limited to 10-15(More)
—This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter-patient variability in the response to propofol infusion(More)
Mobile phones offer huge potential as platforms for clinical decision making in resource-poor and remote areas. We present methods for the development of a human-centered interface for anesthesia monitoring that is targeted to remote operating rooms in developing countries. The Phone Oximeter is compatible with major PC and mobile phone operating systems(More)
A modular framework for the development of medical applications that promotes deterministic, robust and correct code is presented. The system is based on the portable Gambit Scheme programming language and provides a flexible cross-platform environment for developing graphical applications on mobile devices as well as medical instrumentation interfaces(More)
The development of mobile applications for the diagnosis and management of pregnant women with pre-eclampsia is described. These applications are designed for use by community-based health care providers (c-HCPs) in health facilities and during home visits to collect symptoms and perform clinical measurements (including pulse oximeter readings). The(More)
Infectious diseases such as pneumonia take the lives of millions of children in low- and middle-income countries every year. Many of these deaths could be prevented with the availability of robust and low-cost diagnostic tools using integrated sensor technology. Pulse oximetry in particular, offers a unique non-invasive and specific test for an increase in(More)
The photoplethysmogram (PPG) obtained from pulse oximetry shows the local changes of blood volume in tissues. Respiration induces variation in the PPG baseline due to the variation in venous blood return during each breathing cycle. We have proposed an algorithm based on the synchrosqueezing transform (SST) to estimate instantaneous respiratory rate (IRR)(More)
Following purification, the fractions of purified samples typically are analyzed to determine the relative purities of each fraction. We report a novel technique for performing post-purification analysis immediately after each preparative LC/MS run. The Single Pass Compound Purification and Analysis System (SPACPASS) samples and stores a representative(More)
Many aspects of modern medicine, including the administration of anesthetic agents during general surgery, remain unautomated and reliant on the vigilance of the attending clinicians. In other fields where failures can have catastrophic consequences, such as the aviation and nuclear power industry, automated control regimens have been adopted to reduce the(More)