Chris Pacione

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Mammalian RAD51 protein plays essential roles in DNA homologous recombination, DNA repair and cell proliferation. RAD51 activities are regulated by its associated proteins. It was previously reported that a ubiquitin-like protein, UBL1, associates with RAD51 in the yeast two-hybrid system. One function of UBL1 is to covalently conjugate with target proteins(More)
Digital Ink is a design research concept. Part design, part critique, it is the integration of current and future technologies into a mobile and socially familiar object. Digital ink is a sophisticated pen that allows people to take notes, sketch, and save the “physical” data they generate, digitally and automatically. It strives to turn mobile computing(More)
OBJECTIVE Growth factor therapy may be useful for stimulation of cartilage matrix synthesis and repair. Thus, the purpose of our study was to further understand the effect of combined insulin-like growth factor-1 (IGF-1) and osteogenic protein-1 (OP-1) treatment on the matrix synthesized by human adult normal and osteoarthritic (OA) chondrocytes. DESIGN(More)
Bridging the knowing-doing gap in the prevention of chronic disease requires deep appreciation and understanding of the complexities inherent in behavioral change. Strategies that have relied exclusively on the implementation of evidence-based data have not yielded the desired progress. The tools of human-centered design, used in conjunction with(More)
ness with. It was in this world, miles from his birthplace, where the young Fibonacci was first introduced to the concept of a decimal point and 10 strange symbols that looked like these: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9. At the age of 32, after years assisting his father and mastering this system of mathematics, Fibonacci returned to Pisa and published Liber(More)
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