Chris P. Doe
Highly Influential Citations22
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The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation channel that exhibits polymodal activation and is expressed in the endothelium, where it contributes to… Continue Reading
Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates blood pressure homeostasis. We hypothesized that potent and selective ROCK inhibitors with novel structural… Continue Reading
The evidence is compelling for a role of inflammation in cardiovascular diseases; however, the chronic use of anti-inflammatory drugs for these indications has been disappointing. The recent study… Continue Reading
Transient receptor potential V4 (TRPV4), is an osmo/mechano-sensitive ligand-gated non-selective cationic channel that contributes to intracellular Ca2+ homeostasis and regulation of cell volume. T...