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The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were(More)
The ability to control pre-mRNA splicing with small molecules could facilitate the development of therapeutics or cell-based circuits that control gene function. Myotonic dystrophy type 1 is caused by the dysregulation of alternative pre-mRNA splicing due to sequestration of muscleblind-like 1 protein (MBNL1) by expanded, non-coding r(CUG) repeats(More)
BACKGROUND Posttraumatic Stress Disorder (PTSD) is a debilitating psychological condition, never studied in relation to falls in older people. This study determines the prevalence and correlates of PTSD in older people post-fall. METHOD A prospective survey study, with baseline data collected by interview in hospital post-fall and by postal(More)
Foreword Transformative Learning at the University of Central Oklahoma (UCO) is more than simply a value. We intend it as a way of being. We trace TL as a construct at UCO back many ways with High-Impact Practices as described by George Kuh and the Association of American Colleges and Universities (AAC&U) in 2008. More importantly, we consider the Tenets to(More)
A brief summary is given of the Group-Variation Equations and the island diagram confinement mechanism, with an explanation of the prediction that the cylinder-topology minimal-area spanning surface term in the correlation function of two Wilson loops at large N c , when it exists, must have a pre-exponential factor, which for large area A of the(More)
I consider a class of Grand Unified models, in which E8 is broken to SU(3) × SU(2)× 3 to SU(2) diag reduces the SU(2) coupling constant, at unification, by a factor of 1/ √ 3, so that the ratio of the SU(3) and SU(2) diag coupling constants, at unification, is equal to the ratio observed at about 1 TeV. By choosing a suitable alignment of U(1) Y , and(More)
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