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Excessive sun exposure in the first 15 years of life has been shown to be a determinant risk factor for melanoma. This study was conducted on a randomly selected sample of 200 adolescents (13-14 years old) and 150 children (3 years old) in Marseille (South of France). Children and adolescents were examined and interviewed (mothers answered for young(More)
BACKGROUND There is no agreement about surveillance after resection of a stage I melanoma. OBJECTIVE We assessed the cost-effectiveness of this surveillance. METHODS Out of 912 patients with stage I (and Clark's level > or = II) melanoma examined from 1981 to 1991, only 528 were regularly followed in our department. RESULTS 115 out of 528 relapsed;(More)
BACKGROUND AND DESIGN Polymerase chain reaction (PCR) detection of circulating tumor cells from malignant melanoma (MM) was recently described, but the prognostic value of this method in the treatment of patients with MM remained unclear. In the present prospective study, blood samples (n = 193) were collected from 93 patients with MM: 10 stage I patients(More)
BACKGROUND Spontaneous involution of giant keratoacanthomas (KAs) can leave large scars or cause mutilation. Human papillomaviruses have recently been demonstrated in KAs. Intralesional interferon alfa-2a (IFN alfa-2a) has been shown to have activity against different epithelial tumors and to have an antiviral effect. OBJECTIVE This study was conducted to(More)
Prior research characterizes management earnings forecasts (MEFs) as voluntary corporate disclosures designed to increase transparency (i.e., reduce information asymmetry between managers and investors, satisfy analysts " demand for information, lower a firm " s cost of capital, reduce a firm " s litigation risk) or allow managers to trade opportunistically(More)
A case of erosive pustular dermatosis of the scalp is reported. The lesions were eroded with crusting and pustule formation and were localised on the scalp. Investigations for infection, autoimmunity, vascular or tumoral aetiology were negative. Skin biopsy revealed non specific inflammation as usually, but also showed spongiform pustule formations which(More)
Prior studies identify several motives for why firms release management earnings forecasts (MFs). A common feature of such studies is they pool MFs when drawing inferences about a specific motive. By ignoring the heterogeneous rationales managers have to issue MFs, pooling could lead to biased inferences. To address the issue, we develop an approach that(More)