Learn More
BTRFS is a Linux filesystem that has been adopted as the default filesystem in some popular versions of Linux. It is based on copy-on-write, allowing for efficient snapshots and clones. It uses B-trees as its main on-disk data structure. The design goal is to work well for many use cases and workloads. To this end, much effort has been directed to(More)
While it could be said that regenerative medicine is what this journal publishes, that would be cyclical. It could also be claimed that most people interested in the field have a good grasp of what is entailed, and this is probably correct. But, as the field grows and there is a need to carry governments and public opinion along, it is probably worth having(More)
Dynamic mechanical properties of cells are becoming recognized as indicators and regulators of physiological processes such as differentiation, malignant phenotypes and mitosis. A key process in development and homeostasis is apoptosis and whilst the molecular control over this pathway is well studied, little is known about the mechanical consequences of(More)
Managing a fixed amount of memory (RAM) optimally is a long-solved problem in the Linux kernel. Managing RAM optimally in a virtual environment, however, is still a challenging problem because: (1) each guest kernel focuses solely on optimizing its entire fixed RAM allocation oblivious to the needs of other guests, and (2) very little information is exposed(More)
Regenerative medicines based on human cells demand their harvesting, culture, and processing. Manufacturing processes are likely to include cell concentration and subsequent controlled dosing of concentrates, for example, to the patient or tissue construct. The integrity and functionality of the cells must be maintained during these processing stages. In(More)
BACKGROUND Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an(More)