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Managing a fixed amount of memory (RAM) optimally is a long-solved problem in the Linux kernel. Managing RAM optimally in a virtual environment, however , is still a challenging problem because: (1) each guest kernel focuses solely on optimizing its entire fixed RAM allocation oblivious to the needs of other guests, and (2) very little information is(More)
The cell membrane and cytoskeleton are dynamic structures that are strongly influenced by the thermo-mechanical background in addition to biologically driven mechanical processes. We used atomic force microscopy (AFM) to measure the local membrane motion of human foreskin fibroblasts (HFFs) which were found to be governed by random and non-random correlated(More)
BACKGROUND Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an(More)
Conceptually, fast server-side page cache storage could dramatically reduce paging I/O. In this workshop extended abstract, we speculate how such a device might be used, then show how it can be implemented virtually in a hypervisor. We then introduce hcache (pronounced " aitch-cash "), our prototype implementation built on the Xen hypervisor and utilized by(More)
Bioprocess forces such as shear stress experienced during routine cell culture are considered to be harmful to cells. However, the impact of physical forces on cell behavior is an area of growing interest within the tissue engineering community, and it is widely acknowledged that mechanical stimulation including shear stress can enhance osteogenic(More)