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BTRFS is a Linux filesystem that has been adopted as the default filesystem in some popular versions of Linux. It is based on copy-on-write, allowing for efficient snapshots and clones. It uses B-trees as its main on-disk data structure. The design goal is to work well for many use cases and workloads. To this end, much effort has been directed to(More)
Managing a fixed amount of memory (RAM) optimally is a long-solved problem in the Linux kernel. Managing RAM optimally in a virtual environment, however , is still a challenging problem because: (1) each guest kernel focuses solely on optimizing its entire fixed RAM allocation oblivious to the needs of other guests, and (2) very little information is(More)
BACKGROUND Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome. Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an(More)
The cell membrane and cytoskeleton are dynamic structures that are strongly influenced by the thermo-mechanical background in addition to biologically driven mechanical processes. We used atomic force microscopy (AFM) to measure the local membrane motion of human foreskin fibroblasts (HFFs) which were found to be governed by random and non-random correlated(More)
Conceptually, fast server-side page cache storage could dramatically reduce paging I/O. In this workshop extended abstract, we speculate how such a device might be used, then show how it can be implemented virtually in a hypervisor. We then introduce hcache (pronounced " aitch-cash "), our prototype implementation built on the Xen hypervisor and utilized by(More)
Sex in higher diploids carries a two-fold cost of males that should reduce its fitness relative to cloning, and result in its extinction. Instead, sex is widespread and clonal species face early obsolescence. One possible reason is that sex is an adaptation that allows organisms to respond more effectively to endless changes in their environment. The(More)
The commercialisation of human embryonic stem cell derived cell therapies for large patient populations is reliant on both minimising expensive and variable manual-handling methods whilst realising economies of scale. The Quantum Cell Expansion System, a hollow fibre bioreactor (Terumo BCT), was used in a pilot study to expand 60 million human embryonic(More)
Practical experience has indicated that shooting water buffalo with a captive bolt gun in the front of the head does not always produce an effective stun. Slaughtermen have been claiming that the poll position is more reliable, but under present EU regulations this shooting position is not allowed for domesticated bovines. This study examined the(More)
1. Introduction Simulations have become an integral part of a product design workflow, as devices are becoming more complex and development cycles are shrinking to be more competitive and meet market demand. In the last two decades, the capabilities of electromagnetic simulation techniques have vastly expanded to simulate increasingly more realistic and(More)