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We report here the cloning and characterization of two novel PDE4D isoforms, PDE4D6 and PDE4D7. PDE4D6 is a supershort form and PDE4D7 a long form of PDE4D. In addition, we have identified another novel long-form variant, PDE4D8, in silico. Like other isoforms, PDE4D6 and PDE4D7 are differentially expressed. Expression of PDE4D6 is restricted to brain(More)
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The mature publishing and information industries were faced in the mid ‘90’s by the rise of unforeseen technology and unfamiliar digitized formats as proposed vehicles for information which would previously have been presented in the flat environment of print on paper. During this period, publishers and other content providers were frequently chastised for(More)
With the demand for electronic products and desktop access in the past 5-8 years, information providers have had to reorganize their operations to manage and produce digital versions of their publications. They have had to develop new formats and new interfaces while also refocusing business plans to establish new pricing models and collaborative(More)
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