Chris LP Wong

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BACKGROUND Kocuria, previously classified into the genus of Micrococcus, is commonly found on human skin. Two species, K. rosea and K. kristinae, are etiologically associated with catheter-related bacteremia. CASE PRESENTATION We describe the first case of K. kristinae infection associated with acute cholecystitis. The microorganism was isolated from the(More)
In the present study, intestinal motility was measured by the transit of charcoal meal through the small intestine in mice. Morphine, given subcutaneously, caused a dose-dependent slowing of the rate of intestinal transit. This inhibitory effect of morphine was antagonised by prior subcutaneous administration of naloxone hydrochloride or its quaternary(More)
Both clonidine and morphine dose-dependently inhibited intestinal transit in mice. This inhibitory effect of clonidine was antagonized by prior administration of yohimbine but not by naloxone, while morphine's effect was antagonized by both yohimbine and naloxone. Morphine pretreatment did not induce any apparent tolerance to the effect of clonidine and(More)
1. Intraventricular administration of human beta-endorphin and elephant beta-endorphin significantly prolonged the tail flick response tested 30 min later. However, elephant beta-endorphin was about 7-8 times more potent than human beta-endorphin in the tail flick test. 2. beta-Endorphin antagonized the antinociceptive effect of both human beta-endorphin(More)
A 30 sec swim in water at 30 degrees C reduced the writhing response produced in the female mice by i.p. acetic acid. Peripherally administered, naloxone and beta-endorphin1-27 antagonized this swim-induced antinociception. However, i.c.v. administration of these compounds had minimal effects on this phenomenon. beta-Endorphin1-27 was effective in(More)
1. A 30 s swim in water at 30 degrees C reduced the number of abdominal constrictions produced in female mice by intraperitoneally administered acetic acid and this antinociceptive effect was antagonized by naloxone. 2. Oophorectomy abolished the development of antinociceptive activity in response to swim. 3. The development of antinociceptive activity and(More)
A 30 s swim in water at 30 degrees C reduced the number of abdominal constrictions produced in mice by i.p. acetic acid. Naloxone antagonised this stress-induced antinociception in the female but not in the male. Orchidectomy altered neither the antinociception nor its insensitivity to naloxone antagonism. However, oophorectomy completely abolished the(More)
In the present study, the effect of histamine agonists and antagonists on morphine antinociception and naloxone antagonism were studied. The antinociceptive effect of morphine and the antagonistic effect of naloxone were measured by the acetic acid-induced abdominal constriction test in mice. It was found that pretreatment with 2-methylhistamine, a(More)
Both morphine and nalbuphine were effective in suppressing the abdominal constriction response induced by intraperitoneal injection of acetic acid in mice. On a weight to weight basis, nalbuphine was more potent than morphine in this test. However, the effect of nalbuphine was more effectively blocked by naloxone. Pretreatment with morphine 2.0 mg/kg(More)
Using the abdominal constriction test in mice it was shown that the antinociceptive effect of morphine was inhibited by naloxone hydrochloride and its quaternary derivative naloxone methylbromide which presumably only acts peripherally. Pretreatment with a single dose of morphine 2.0 mg/kg s.c. did not alter the antinociceptive effect of a second dose of(More)