Chris Kimble

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Deep Brain Stimulation (DBS) provides therapeutic benefit for several neuropathologies including Parkinson's disease (PD), epilepsy, chronic pain, and depression. Despite well established clinical efficacy, the mechanism(s) of DBS remains poorly understood. In this review we begin by summarizing the current understanding of the DBS mechanism. Using this(More)
Subthalamic nucleus deep brain stimulation (STN DBS) ameliorates motor symptoms of Parkinson's disease, but the precise mechanism is still unknown. Here, using a large animal (pig) model of human STN DBS neurosurgery, we utilized fast-scan cyclic voltammetry in combination with a carbon-fiber microelectrode (CFM) implanted into the striatum to monitor(More)
OBJECTIVES The evaluation of telemedicine from the patient's point of view has focused on the patient pathway and patient satisfaction. However, research in this field does not provide us with the means to assess a patient's perception of the procedure if their reasoning ability is impaired. In this study, we use direct observation of a patient's behavior(More)
Knowledge Management (KM) initiatives promote the management, i.e. the creation, storage and sharing, of knowledge assets within an organization. The practical focus of this special issue is to bring together researchers, professionals and practitioners to present recent developments on the knowledge and competence management areas. KM focuses on techniques(More)
This is a descriptive article focusing on the eDENT project, the first oral tele-consultation in France; an experimentation of asynchronous dental tele-consultations meant to improve access to dental care for people who have limited access to regular consultations with a dentist such as dependent elderly, disabled people or prisoners. We consider that the(More)