Chris Kimble

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Deep Brain Stimulation (DBS) provides therapeutic benefit for several neuropathologies including Parkinson's disease (PD), epilepsy, chronic pain, and depression. Despite well established clinical efficacy, the mechanism(s) of DBS remains poorly understood. In this review we begin by summarizing the current understanding of the DBS mechanism. Using this(More)
Subthalamic nucleus deep brain stimulation (STN DBS) ameliorates motor symptoms of Parkinson's disease, but the precise mechanism is still unknown. Here, using a large animal (pig) model of human STN DBS neurosurgery, we utilized fast-scan cyclic voltammetry in combination with a carbon-fiber microelectrode (CFM) implanted into the striatum to monitor(More)
Modern commercial organisations are facing pressures which have caused them to lose personnel. When they lose people, they also lose their knowledge. Organisations also have to cope with the internationalisation of business forcing collaboration and knowledge sharing across time and distance. Knowledge management (KM) claims to tackle these issues. This(More)
Knowledge Management (KM) is a field that has attracted much attention both in academic and practitioner circles. Most KM projects appear to be primarily concerned with knowledge that can be quantified and can be captured, codified and stored an approach more deserving of the label Information Management. Recently there has been recognition that some(More)
Purpose – This main aim of this article is to explore the relationship between knowledge management (KM) and communities of practice (CoPs) in general and virtual CoPs in particular. A subsidiary aim is to provide some practical guidelines about how virtual CoPs can be facilitated and maintained. Design/methodology/approach – The relationship between KM and(More)
The article examines the process of innovation and knowledge sharing from a perspective that focuses on the influence that local circumstances can have. In particular, it looks at the problems of knowledge sharing between groups of professionals. It presents a comparative analysis of two studies, one involving two groups of IT professionals; the other a(More)
Introduction: The strategies that people use to browse Websites are difficult to analyse and understand: quantitative data can lack information about what a user actually intends to do, while qualitative data tends to be localised and is impractical to gather for large samples. Method: This paper describes a novel approach that combines data from direct(More)
Knowledge management is fast becoming a commercial necessity for many organizations, in order that they manage their intellectual assets and gain competitive advantage. To maximise that advantage, knowledge management needs to be available across the whole of the enterprise. Before a knowledge management system can be built, the knowledge that pervades the(More)