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The stability of the Wnt pathway transcription factor beta-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers, making this pathway an attractive target for anticancer therapies. However, the development of targeted Wnt pathway inhibitors has been hampered by the limited(More)
A JDI (Journal Descriptor Indexing) tool has been developed at NLM that automatically categorizes biomedical text as input, returning a ranked list, with scores between 0-1, of either JDs (Journal Descriptors, corresponding to biomedical disciplines) or STs (UMLS Semantic Types). Possible applications include WSD (Word Sense Disambiguation) and retrieval(More)
1. Introduction The demand for natural language processing (NLP) in medicine has grown significantly in recent years. This growth is expected to increase rapidly due to the continuing adoption of electronic medical records (EMRs). Medical language processing (MLP) seeks to analyze linguistic patterns found not only in electronic medical records, but also in(More)
The SPECIALIST Lexicon has been distributed annually by the National Library of Medicine (NLM) since 1994. Lexical records are used for Part-of-Speech (POS) tagging, indexing, information retrieval, concept mapping, etc. in many Natural Language Processing (NLP) projects, such as Lexical Tools, MetaMap, SemRep, UMLS Metathesaurus, and ClinicalTrials.gov.(More)
Previous studies on cancer cell invasion were primarily focused on its migration because these two events were often considered biologically equivalent. Here we found that T24T cells exhibited higher invasion but lower migration abilities than T24 cells. Expression of Rho-GDPases was much lower and expression of SOD2 was much higher in T24T cells than those(More)
It is always a challenge to present Web applications at a facility with no Internet connection. Traditional presentation methods such as transparencies or slides are inadequate for demonstrating dynamic Web applications. Currently, virtual-live demonstrations of Web applications are created with static HTML (Hypertext Markup Language) files. However,(More)