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Recently, the demand for data center computing has surged, increasing the total energy footprint of data centers worldwide. Data centers typically comprise three subsystems: IT equipment provides services to customers; power infrastructure supports the IT and cooling equipment; and the cooling infrastructure removes heat generated by these subsystems. This(More)
We present a high level overview of a virtual machine placement system in which an autonomic controller dynamically manages the mapping of virtual machines onto physical hosts in accordance with policies specified by the user. By closely monitoring virtual machine activity and employing advanced policies for dynamic workload placement, such an autonomic(More)
Recent advances in hardware and software virtualization offer unprecedented management capabilities for the mapping of virtual resources to physical resources. It is highly desirable to further create a " service hosting abstraction " that allows application owners to focus on service level objectives (SLOs) for their applications. This calls for a resource(More)
Recent advances in hardware and software virtu-alization offer unprecedented management capabilities for the mapping of virtual resources to physical resources. It is highly desirable to further create a " service hosting abstraction " that allows application owners to focus on service level objectives (SLOs) for their applications. This calls for a(More)
—Data centers contain IT, power and cooling infras-tructures, each of which is typically managed independently. In this paper, we propose a holistic approach that couples the management of IT, power and cooling infrastructures to improve the efficiency of data center operations. Our approach considers application performance management, dynamic workload(More)
Reduction of resource consumption in data centers is becoming a growing concern for data center designers, operators and users. Accordingly, interest in the use of renewable energy to provide some portion of a data center's overall energy usage is also growing. One key concern is that the amount of renewable energy necessary to satisfy a typical data(More)
—Managing application-level performance for multi-tier applications in virtualized server environments is challenging because the applications are distributed across multiple virtual machines, and workloads are dynamic in their intensity and transaction mix resulting in time-varying resource demands. In this paper, we present AppRAISE, a system that manages(More)
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder for which the biochemical defect is as yet unknown. Recently, two cloned segments of human X-chromosome DNA have been described which detect structural alterations within or near the genetic locus responsible for the disorder. Both of these cloned segments were described as tightly(More)
—Public and private cloud computing environments typically employ virtualization methods to consolidate application workloads onto shared servers. Modern servers typically have one or more sockets each with one or more computing cores, a multi-level caching hierarchy, a memory subsystem, and an interconnect to the memory of other sockets. While resource(More)
The recent identification of the gene and gene product altered in Duchenne and Becker dystrophy has opened up new and exciting avenues to an understanding of these diseases. This article presents the clinical features, pathology, genetics, and management of Duchenne and Becker muscular dystrophy. These issues are discussed in light of the rapidly(More)