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Recently, the demand for data center computing has surged, increasing the total energy footprint of data centers worldwide. Data centers typically comprise three subsystems: IT equipment provides services to customers; power infrastructure supports the IT and cooling equipment; and the cooling infrastructure removes heat generated by these subsystems. This(More)
We present a high level overview of a virtual machine placement system in which an autonomic controller dynamically manages the mapping of virtual machines onto physical hosts in accordance with policies specified by the user. By closely monitoring virtual machine activity and employing advanced policies for dynamic workload placement, such an autonomic(More)
Recent advances in hardware and software virtualization offer unprecedented management capabilities for the mapping of virtual resources to physical resources. It is highly desirable to further create a "service hosting abstraction" that allows application owners to focus on service level objectives (SLOs) for their applications. This calls for a resource(More)
Recent advances in hardware and software virtu-alization offer unprecedented management capabilities for the mapping of virtual resources to physical resources. It is highly desirable to further create a " service hosting abstraction " that allows application owners to focus on service level objectives (SLOs) for their applications. This calls for a(More)
Reduction of resource consumption in data centers is becoming a growing concern for data center designers, operators and users. Accordingly, interest in the use of renewable energy to provide some portion of a data center's overall energy usage is also growing. One key concern is that the amount of renewable energy necessary to satisfy a typical data(More)
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder for which the biochemical defect is as yet unknown. Recently, two cloned segments of human X-chromosome DNA have been described which detect structural alterations within or near the genetic locus responsible for the disorder. Both of these cloned segments were described as tightly(More)
Data centers contain IT, power and cooling infrastructures, each of which is typically managed independently. In this paper, we propose a holistic approach that couples the management of IT, power and cooling infrastructures to improve the efficiency of data center operations. Our approach considers application performance management, dynamic workload(More)
Members of an international consortium for linkage analysis of the facioscapulohumeral muscular dystrophy (FSHD) gene have pooled data for joint analyses, in an attempt to determine the precise location of the FSHD gene and the order of four DNA markers on 4q35 region. Six laboratories determined a total of 3,078 genotypes in 65 families, consisting of a(More)
The genetic locus for facioscapulohumeral muscular dystrophy (FSHD) has been mapped to chromosome 4. We have examined linkage to five chromosome 4q DNA markers in 22 multigenerational FSHD families. Multipoint linkage analyses of the segregation of four markers in the FSHD families and in 40 multigenerational mapping families from the Centre d'Etude du(More)
We evaluated 173 patients in the Clinical Investigation of Duchenne Dystrophy study to determine if patients from the same kindred were more alike clinically than patients within the study population as a whole. A high intrafamilial correlation was noted for age-adjusted muscle strength scores. While noninherited factors could, in part, explain the results,(More)